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["Cost effectiveness of cabazitaxel for the second line treatment of hormone refractory metastatic prostate cancer"]
[]
[]
[]
["Research question:"]
[null,"To assess the cost-effectiveness of cabazitaxel within its licensed indication for the second \nline treatment of "]
[null,"hormone refractory, metastatic prostate cancer that has progressed following or during docetaxel-based treatment."]
[]
["Patient population:"]
[null,"Men who have hormone refractory metastatic prostate cancer that has progressed following or during docetaxel based treatment"]
[]
[]
["Alternative (treatment) options:"]
[1,"Cabazitaxel in combination with prednisolone"]
[2,"Mitoxantrone in combination with prednisolone"]
[]
["Perspective"]
[null,"NHS"]
[]
["Costs considered in the model:"]
[1,"costs of treatment (caba+ and mito+)",null,null,3,"costs of care after progression"]
[2,"costs of follow up during progression free survival",null,null,4,"costs of adverse events"]
[]
["Health outcomes considered in the model:"]
[1,"survival ",null,null,2,"quality of life"]
[]
["Health states in the model:"]
[1,"Stable disease / progression free"]
[2,"Progressive disease"]
[3,"Dead"]
[]
["Time horizon of the model:"]
[null,"15 years "]
[]
["Cycle duration"]
[null,"3 weeks"]
[]
["Diagrammatical representation of the model structure:"]

{"sheet":"Analysis","index":1,"n_rows":60,"n_cols":7,"rows_kept":60,"cut":false,"hidden":false,"merged":[[0,0,0,8],[2,0,2,8]]}
[{"$f":"'Project info'!A1","v":"Cost effectiveness of cabazitaxel for the second line treatment of hormone refractory metastatic prostate cancer"}]
[]
["ANALYSIS"]
[]
[null,null,null,"Probabilistic analysis?"]
[]
[null,null,null,null,0]
[null,null,null,null,"0 = deterministic, 1 = probabilistic"]
[]
[]
[]
["Results (deterministic) - discounted, with half cycle correction",null,"This section should be filled in as part of the deterministic assignment"]
[]
["Treatment",null,"Costs",null,"QALY",null,"LY"]
["Cabazitaxel in combination with prednisolone",null,{"$f":"total_cost_caba","v":28687.31630730514},null,{"$f":"total_QALY_caba","v":1.1549826005648856},null,{"$f":"total_LY_caba","v":1.7718260674775839}]
["Mitoxantrone in combination with prednisolone",null,{"$f":"total_cost_mito","v":24124.797957953193},null,{"$f":"total_QALY_mito","v":0.87427001814824767},null,{"$f":"total_LY_mito","v":1.3460644992023172}]
["Increment",null,{"$f":"C15-C16","v":4562.5183493519471},null,{"$f":"E15-E16","v":0.28071258241663788},null,{"$f":"G15-G16","v":0.42576156827526668}]
[null,null,null,null,"incremental costs/",null,"incremental costs/"]
["ICERs:",null,null,null,"QALY",null,"LY"]
["Cabazitaxel vs mitoxantrone",null,null,null,{"$f":"C17/E17","v":16253.344649083767},null,{"$f":"C17/G17","v":10716.134778990086}]
[]
[]
["Results (probabilistic)",null,"This section should be filled in as part of the PSA assignment"]
[]
["Treatment",null,"Costs",null,"QALY",null,"LY"]
["Cabazitaxel in combination with prednisolone",null,{"$f":"PSA_CostCaba_mean","v":28802.409304909856},null,{"$f":"PSA_QALYCaba_mean","v":1.1588919387459962},null,{"$f":"PSA_LYCaba_mean","v":1.7788891845249564}]
["Mitoxantrone in combination with prednisolone",null,{"$f":"PSA_CostMito_mean","v":24207.278655533533},null,{"$f":"PSA_QALYMito_mean","v":0.87672154787753798},null,{"$f":"PSA_LYMito_mean","v":1.3504808419386261}]
["Increment",null,{"$f":"C26-C27","v":4595.1306493763223},null,{"$f":"E26-E27","v":0.28217039086845819},null,{"$f":"G26-G27","v":0.42840834258633032}]
[null,null,null,null,"incremental costs/",null,"incremental costs/"]
["ICERs:",null,null,null,"QALY",null,"LY"]
["Cabazitaxel vs mitoxantrone",null,null,null,{"$f":"C28/E28","v":16284.949796587531},null,{"$f":"C28/G28","v":10726.053142745088}]
[]
[]
[]
["Disaggregated Results (deterministic) - discounted, half cycle correction",null,"This section should be filled in as part of the deterministic assignment"]
[]
["Treatment","Cabazitaxel in combination with prednisolone","Mitoxantrone in combination with prednisolone","Increment"]
[]
["Drug acquisition costs - SD",{"$f":"total_c_drug_acquisition_SD_caba","v":793.44547393995856},{"$f":"total_c_drug_acquisition_SD_mito","v":817.31168278686391},{"$f":"B39-C39","v":-23.866208846905351}]
["Chemo admin costs - SD",{"$f":"total_c_chemo_admin_SD_caba","v":2324.0856703411114},{"$f":"total_c_chemo_admin_SD_mito","v":2070.8910881423913},{"$f":"B40-C40","v":253.19458219872013}]
["Premed costs SD",{"$f":"total_c_premed_SD_caba","v":426.04390911599819},{"$f":"total_c_premed_SD_mito","v":141.36445527174948},284.67945384424871]
["Concomitant costs SD",{"$f":"total_c_concomitant_SD_caba","v":480.1817881083727},{"$f":"total_c_concomitant_SD_mito","v":349.62930342330066},130.55248468507205]
["HC resource use costs SD",{"$f":"total_c_HC_resource_use_SD_caba","v":2192.466517899084},{"$f":"total_c_HC_resource_use_SD_mito","v":1596.3757068999105},596.09081099917353]
["AE costs SD",{"$f":"total_c_AE_SD_caba","v":947.48844962064788},{"$f":"total_c_AE_SD_mito","v":481.82278340838485},465.66566621226303]
[]
["Drug acquisition costs post-progression chemo - PD",{"$f":"total_c_drug_acquisition_PD_caba","v":730.82530975789064},{"$f":"total_c_drug_acquisition_PD_mito","v":663.13478596783716},{"$f":"B46-C46","v":67.690523790053476}]
["Chemo admin costs - PD",{"$f":"total_c_chemo_admin_PD_caba","v":2360.0221497188027},{"$f":"total_c_chemo_admin_PD_mito","v":2303.5549924314346},56.467157287368082]
["Premed costs PD",{"$f":"total_c_premed_PD_caba","v":161.10129959732714},{"$f":"total_c_premed_PD_mito","v":157.24670339167446},3.8545962056526832]
["Concomitant costs PD",{"$f":"total_c_concomitant_PD_caba","v":1908.4169334581597},{"$f":"total_c_concomitant_PD_mito","v":1465.0002479513439},443.41668550681584]
["HC resource use PD",{"$f":"total_c_HC_resource_use_PD_caba","v":9027.7019149957359},{"$f":"total_c_HC_resource_use_PD_mito","v":6930.134244792127},2097.5676702036089]
["BSC costs",{"$f":"total_c_BSC_PD_caba","v":1296.1950654079967},{"$f":"total_c_BSC_PD_mito","v":995.02685127356267},301.16821413443404]
[]
["End of life costs ",{"$f":"total_c_end_of_life_PD_caba","v":6039.3418253440677},{"$f":"total_c_end_of_life_PD_mito","v":6153.3051122126117},{"$f":"B53-C53","v":-113.96328686854395}]
[]
["LYs accrued in SD state",{"$f":"total_LY_SD_caba","v":0.35619151999730936},{"$f":"total_LY_SD_mito","v":0.25934967986299229},{"$f":"B55-C55","v":9.684184013431707E-2}]
["LYs accrued in PD state",{"$f":"total_LY_PD_caba","v":1.4156345474802772},{"$f":"total_LY_PD_mito","v":1.0867148193393246},{"$f":"B56-C56","v":0.32891972814095261}]
[]
["QALYs accrued in SD state",{"$f":"total_QALY_SD_caba","v":0.27115903996306828},{"$f":"total_QALY_SD_mito","v":0.1950123102684467},{"$f":"B58-C58","v":7.6146729694621579E-2}]
["QALYs accrued in PD state",{"$f":"total_QALY_PD_caba","v":0.88760286127013321},{"$f":"total_QALY_PD_mito","v":0.68137019172575664},{"$f":"B59-C59","v":0.20623266954437658}]
["QALYs lost due to adverse events",{"$f":"total_QALY_loss_AE_caba","v":3.7793006683159176E-3},{"$f":"total_QALY_loss_AE_mito","v":2.1124838459550275E-3},{"$f":"B60-C60","v":1.6668168223608901E-3}]

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[]
[]
[]
["Parameter name","Value","Description","Source and description"]
[]
["Discount rates"]
["cDR",3.5000000000000003E-2,"Cost discount rate","Methods guide NICE"]
["oDR",3.5000000000000003E-2,"Outcome discount rate","Methods guide NICE"]
[]
["Choice of distribution OS and PFS"]
["Distribution_OS",4,"1 for exponential, 2 for Weibull, 3 for lognormal, 4 for loglogistic","AIC of lognormal and loglogsitic for cabazitaxel and mitoxantrone were relatively low, compared to other distributions. Visually loglogistic follows both KM curves well."]
["Distribution_PFS",2,"1 for exponential, 2 for Weibull, 3 for lognormal, 4 for loglogistic","For cabazitaxel the AIC of exponential, weibull and lognormal were comparably low, for mitoxantrone the AIC of lognormal and loglogistic were relatively low, exponential and weibull were higher. BUT visually for cabazitaxel weibull and exponential follow curve well, the others don't follow curve at all, for mitoxantrone nothing follows perfectly, so no preference. But because visually for cabazitaxel there was a big preference, we chose Weibull."]
[]
[]
[]
["Parameter name","Value","Probabilistic","Deterministic","Standard error","Distribution","Number of cases","Number of non-cases",null,"Description","Source"]
[null,null,null,null,null,null,"If you have an alpha and beta from your data source, fill these in here. If results were reported with a standard error, or if you need to assume a value for the SE, use the formulae from the method of moments"]
[]
[]
[]
["Time"]
["Days a year",{"$f":"IF(Ind_PSA=0,D22,C22)","v":365},{"$f":"D22","v":365},365,null,"fixed",null,null,null,"Note: some modelles use 365.25 to account for leap years. This would be a bit more accurate, but not implemented her"]
["Weeks in a year",{"$f":"IF(Ind_PSA=0,D23,C23)","v":52},{"$f":"D23","v":52},52,null,"fixed",null,null,null,"This is the amount of weeks in a year"]
["Cycle length (weeks)",{"$f":"IF(Ind_PSA=0,D24,C24)","v":3},{"$f":"D24","v":3},{"$f":"3","v":3},null,"fixed",null,null,null,"This is the amount of weeks in one cycle"]
["Cycle length (days)",{"$f":"IF(Ind_PSA=0,D25,C25)","v":21},{"$f":"D25","v":21},21,null,"fixed",null,null,null,"This is the amount of days in one cycle"]
["Cycle length (weeks/year)",{"$f":"IF(Ind_PSA=0,D26,C26)","v":5.7692307692307696E-2},{"$f":"cycle_length_weeks/weeks_in_a_year","v":5.7692307692307696E-2},{"$f":"cycle_length_weeks/weeks_in_a_year","v":5.7692307692307696E-2},null,"fixed",null,null,null,"This value is used to convert the number of people in a health state to LYs and QALYs"]
[]
["Cohort size",{"$f":"IF(Ind_PSA=0,D28,C28)","v":1000},{"$f":"D28","v":1000},1000,null,"fixed",null,null,null,"This is the cohort size"]
["Calculation minutes to hours",{"$f":"IF(Ind_PSA=0,D29,C29)","v":1.6666666666666666E-2},{"$f":"D29","v":1.6666666666666666E-2},{"$f":"1/60","v":1.6666666666666666E-2},null,"fixed",null,null,null,"This value is used to convert the amount of minutes to the amount of hours"]
["Calculation days to hours",{"$f":"IF(Ind_PSA=0,D30,C30)","v":24},{"$f":"D30","v":24},{"$f":"24","v":24},null,"fixed",null,null,null,"This value is used to convert the amount of days to the amount of hours"]
["Amount of weeks in 3 months",{"$f":"IF(Ind_PSA=0,D31,C31)","v":13},{"$f":"D31","v":13},{"$f":"13","v":13},null,"fixed",null,null,null,"This value is used to calculate the health care resources from 3 months to 3 each 3-week cycle.","This was given in the assignment under 2.1.5"]
[]
["Patient characteristics"]
["Percentage used for SE calculation body surface and weight",{"$f":"IF(Ind_PSA=0,D34,C34)","v":0.05},{"$f":"D34","v":0.05},0.05,null,"fixed",null,null,null,"Assumed percentage used for SE calculation for average body surface and weight","The assumption is based on information from: De Bono et al., 2010"]
["Average body surface area in m2",{"$f":"IF(Ind_PSA=0,D35,C35)","v":2.0099999999999998},{"$f":"GAMMAINV(RAND(),G35,H35)","v":1.9907119742802508},2.0099999999999998,{"$f":"perc_SE_bodysurface_and_weight*D35","v":0.10049999999999999},"gamma",{"$f":"(D35^2)/(E35^2)","v":399.99999999999994},{"$f":"(E35^2)/(D35)","v":5.025E-3},null,"Assumed average body surface area in m2","De Bono et al., 2010"]
["Average body weight (kg)",{"$f":"IF(Ind_PSA=0,D36,C36)","v":70},{"$f":"GAMMAINV(RAND(),G36,H36)","v":70.010678898930834},70,{"$f":"perc_SE_bodysurface_and_weight*D36","v":3.5},"gamma",{"$f":"(D36^2)/(E36^2)","v":400},{"$f":"(E36^2)/(D36)","v":0.17499999999999999},null,"Assumed average body weight in kg","De Bono et al., 2010"]
[]
["Inflation (Annual increase on previous years)"]
["NHSCII price 2015/2016",{"$f":"IF(Ind_PSA=0,D39,C39)","v":1.004},{"$f":"D39","v":1.004},{"$f":"1 + 0.4/100","v":1.004},null,"fixed",null,null,null,"This is the index rate from 2015/2016","Table 12.1.1: The NHS Cost Inflation Index from the Unit Costs of Health and Social Care 2024 – version 2"]
["NHSCII price 2016/2017",1.0208999999999999,{"$f":"D40","v":1.0208999999999999},{"$f":"1+2.09/100","v":1.0208999999999999},null,"fixed",null,null,null,"This is the index rate from 2016/2017","Table 12.1.1: The NHS Cost Inflation Index from the Unit Costs of Health and Social Care 2024 – version 2"]
["NHSCII price 2017/2018",1.0124,1.0124,{"$f":"1+1.24/100","v":1.0124},null,"fixed",null,null,null,"This is the index rate from 2017/2018","Table 12.1.1: The NHS Cost Inflation Index from the Unit Costs of Health and Social Care 2024 – version 2"]
["NHSCII price 2018/2019",1.016,1.016,{"$f":"1+1.6/100","v":1.016},null,"fixed",null,null,null,"This is the index rate from 2018/2019","Table 12.1.1: The NHS Cost Inflation Index from the Unit Costs of Health and Social Care 2024 – version 2"]
["NHSCII price 2019/2020",1.0214000000000001,1.0214000000000001,{"$f":"1+2.14/100","v":1.0214000000000001},null,"fixed",null,null,null,"This is the index rate from 2019/2020","Table 12.1.1: The NHS Cost Inflation Index from the Unit Costs of Health and Social Care 2024 – version 2"]
["NHSCII price 2020/2021",1.0248999999999999,1.0248999999999999,{"$f":"1+2.49/100","v":1.0248999999999999},null,"fixed",null,null,null,"This is the index rate from 2020/2021","Table 12.1.1: The NHS Cost Inflation Index from the Unit Costs of Health and Social Care 2024 – version 2"]
["NHSCII price 2021/2022",1.0258,1.0258,{"$f":"1+2.58/100","v":1.0258},null,"fixed",null,null,null,"This is the index rate from 2021/2022","Table 12.1.1: The NHS Cost Inflation Index from the Unit Costs of Health and Social Care 2024 – version 2"]
["NHSCII price 2022/2023",1.0731999999999999,1.0731999999999999,{"$f":"1+7.32/100","v":1.0731999999999999},null,"fixed",null,null,null,"This is the index rate from 2022/2023","Table 12.1.1: The NHS Cost Inflation Index from the Unit Costs of Health and Social Care 2024 – version 2"]
["NHSCII price 2023/2024",1.0430999999999999,1.0430999999999999,{"$f":"1+4.31/100","v":1.0430999999999999},null,"fixed",null,null,null,"This is the index rate from 2023/2024","Table 12.1.1: The NHS Cost Inflation Index from the Unit Costs of Health and Social Care 2024 – version 2"]
[]
["Health state utility values"]
["SD cycle1",{"$f":"IF(Ind_PSA=0,D50,C50)","v":0.70399999999999996},{"$f":"_xlfn.BETA.INV(RAND(),G50,H50)","v":0.72251328866339704},0.70399999999999996,3.3000000000000002E-2,"beta",{"$f":"D50*((D50*(1-D50))/E50^2-1)","v":134.00888888888886},{"$f":"(1-D50)*((D50*(1-D50))/(E50^2)-1)","v":56.344646464646466},null,"Utility value for stable disease in cycle 1 - The health state utilities will be used for both Cabazitaxel and Mitoxantrone.","NICE TA391, Pre-meeting briefing document, Table 10. Values are derived from the UK Early Access Programme for cabazitaxel"]
["SD cycle2",{"$f":"IF(Ind_PSA=0,D51,C51)","v":0.72799999999999998},0.73588989081441025,0.72799999999999998,2.1000000000000001E-2,"beta",{"$f":"D51*((D51*(1-D51))/E51^2-1)","v":326.15555555555551},{"$f":"(1-D51)*((D51*(1-D51))/(E51^2)-1)","v":121.86031746031745},null,"Utility value for stable disease in cycle 2","NICE TA391, Pre-meeting briefing document, Table 10. Values are derived from the UK Early Access Programme for cabazitaxel"]
["SD cycle3",0.72799999999999998,0.72666935195904803,0.72799999999999998,3.3000000000000002E-2,"beta",131.64633241505967,49.18654178145087,null,"Utility value for stable disease in cycle 3","NICE TA391, Pre-meeting briefing document, Table 10. Values are derived from the UK Early Access Programme for cabazitaxel"]
["SD cycle4",0.75,0.81021545179499643,0.75,{"$f":"0.026","v":2.5999999999999999E-2},"beta",207.2751479289941,69.091715976331372,null,"Utility value for stable disease in cycle 4","NICE TA391, Pre-meeting briefing document, Table 10. Values are derived from the UK Early Access Programme for cabazitaxel"]
["SD cycle5",0.753,0.71929160635010059,0.753,{"$f":"0.035","v":3.5000000000000003E-2},"beta",113.5745289795918,37.254858775510193,null,"Utility value for stable disease in cycle 5","NICE TA391, Pre-meeting briefing document, Table 10. Values are derived from the UK Early Access Programme for cabazitaxel"]
["SD cycle6",0.752,0.72219073677673307,0.752,{"$f":"0.024","v":2.4E-2},"beta",242.72888888888889,80.048888888888882,null,"Utility value for stable disease in cycle 6","NICE TA391, Pre-meeting briefing document, Table 10. Values are derived from the UK Early Access Programme for cabazitaxel"]
["SD cycle7",0.77800000000000002,0.79216970560330424,0.77800000000000002,{"$f":"0.042","v":4.2000000000000003E-2},"beta",75.397197278911548,21.514367346938769,null,"Utility value for stable disease in cycle 7","NICE TA391, Pre-meeting briefing document, Table 10. Values are derived from the UK Early Access Programme for cabazitaxel"]
["SD cycle8",0.78900000000000003,0.76342144197753503,0.78900000000000003,{"$f":"0.034","v":3.4000000000000002E-2},"beta",112.83723788927334,30.175737889273346,null,"Utility value for stable disease in cycle 8","NICE TA391, Pre-meeting briefing document, Table 10. Values are derived from the UK Early Access Programme for cabazitaxel"]
["SD cycle9",0.80300000000000005,0.81308354642395764,0.80300000000000005,{"$f":"0.048","v":4.8000000000000001E-2},"beta",54.33040842013888,13.32887977430555,null,"Utility value for stable disease in cycle 9","NICE TA391, Pre-meeting briefing document, Table 10. Values are derived from the UK Early Access Programme for cabazitaxel"]
["SD cycle 10 and after",0.81899999999999995,0.787488182927224,0.81899999999999995,{"$f":"0.033","v":3.3000000000000002E-2},"beta",{"$f":"D59*((D59*(1-D59))/E59^2-1)","v":110.66652892561983},24.457438016528933,null,"Utility value for stable disease in cycle 10 and after","NICE TA391, Pre-meeting briefing document, Table 10. Values are derived from the UK Early Access Programme for cabazitaxel"]
["Progressed disease ",0.627,0.64778126891884957,0.627,{"$f":"0.019","v":1.9E-2},"beta",405.57,241.2721052631579,null,"Utility value for progressed disease - This utility value is constant over time.","NICE TA391, Pre-meeting briefing document, Table 10. Values are derived from the UK Early Access Programme for cabazitaxel"]
[]
["Incidence of adverse events Cabazitaxel"]
["Total patients (N)",{"$f":"IF(Ind_PSA=0,D63,C63)","v":371},{"$f":"D63","v":371},{"$f":"371","v":371},null,"fixed",null,null,null,"Total number of patients recieving at least one dose of Cabazitaxel","Bono et al., 2010, Table 4"]
["Neutropenia",0.81671159029649598,{"$f":"_xlfn.BETA.INV(RAND(),G64,H64)","v":0.82927127555148106},{"$f":"G64/Caba_total_patients","v":0.81671159029649598},null,"beta",{"$f":"303","v":303},{"$f":"Caba_total_patients-G64","v":68},null,"Incidence of neutropenia for patients with Cabazitaxel","Bono et al., 2010, Table 4"]
["Febrile neutropenia ",7.5471698113207544E-2,6.3207732036173539E-2,{"$f":"G65/Caba_total_patients","v":7.5471698113207544E-2},null,"beta",{"$f":"28","v":28},{"$f":"Caba_total_patients-G65","v":343},null,"Incidence of febrile neutropenia for patients with Cabazitaxel","Bono et al., 2010, Table 4"]
["Leukopenia ",0.68194070080862534,0.69575700807958962,{"$f":"G66/Caba_total_patients","v":0.68194070080862534},null,"beta",{"$f":"253","v":253},{"$f":"Caba_total_patients-G66","v":118},null,"Incidence of leukopenia for patients with Cabazitaxel","Bono et al., 2010, Table 4"]
["Anaemia ",0.10512129380053908,0.12805203437528234,{"$f":"G67/Caba_total_patients","v":0.10512129380053908},null,"beta",{"$f":"39","v":39},{"$f":"Caba_total_patients-G67","v":332},null,"Incidence of anaemia for patients with Cabazitaxel","Bono et al., 2010, Table 4"]
["Diarrhoea ",6.1994609164420483E-2,5.7552268851298084E-2,{"$f":"G68/Caba_total_patients","v":6.1994609164420483E-2},null,"beta",{"$f":"23","v":23},{"$f":"Caba_total_patients-G68","v":348},null,"Incidence of diarrhoea for patients with Cabazitaxel","Bono et al., 2010, Table 4"]
["Fatigue ",4.8517520215633422E-2,4.2573968346626766E-2,{"$f":"G69/Caba_total_patients","v":4.8517520215633422E-2},null,"beta",{"$f":"18","v":18},{"$f":"Caba_total_patients-G69","v":353},null,"Incidence of fatigue for patients with Cabazitaxel","Bono et al., 2010, Table 4"]
["Asthenia ",4.5822102425876012E-2,6.0699572911447897E-2,{"$f":"G70/Caba_total_patients","v":4.5822102425876012E-2},null,"beta",{"$f":"17","v":17},{"$f":"Caba_total_patients-G70","v":354},null,"Incidence of asthenia for patients with Cabazitaxel","Bono et al., 2010, Table 4"]
["Incidence of adverse events Mitoxantrone"]
["Total patients (N)",{"$f":"IF(Ind_PSA=0,D72,C72)","v":371},{"$f":"D72","v":371},{"$f":"371","v":371},null,"fixed",null,null,null,"Total number of patients recieving at least one dose of Mitoxantrone","Bono et al., 2010, Table 4"]
["Neutropenia",0.57951482479784366,{"$f":"_xlfn.BETA.INV(RAND(),G73,H73)","v":0.59373824215981574},{"$f":"G73/mito_total_patients","v":0.57951482479784366},null,"beta",{"$f":"215","v":215},{"$f":"mito_total_patients-G73","v":156},null,"Incidence of neutropenia for patients with Mitoxantrone","Bono et al., 2010, Table 4"]
["Febrile neutropenia ",1.3477088948787063E-2,1.6855429174347902E-2,{"$f":"G74/mito_total_patients","v":1.3477088948787063E-2},null,"beta",{"$f":"5","v":5},{"$f":"mito_total_patients-G74","v":366},null,"Incidence of febrile neutropenia for patients with Mitoxantrone","Bono et al., 2010, Table 4"]
["Leukopenia ",0.42318059299191374,0.39519662282176909,{"$f":"G75/mito_total_patients","v":0.42318059299191374},null,"beta",{"$f":"157","v":157},{"$f":"mito_total_patients-G75","v":214},null,"Incidence of leukopenia for patients with Mitoxantrone","Bono et al., 2010, Table 4"]
["Anaemia ",4.8517520215633422E-2,3.7042043105995202E-2,{"$f":"G76/mito_total_patients","v":4.8517520215633422E-2},null,"beta",{"$f":"18","v":18},{"$f":"mito_total_patients-G76","v":353},null,"Incidence of anaemia for patients with Mitoxantrone","Bono et al., 2010, Table 4"]
["Diarrhoea ",2.6954177897574125E-3,8.3485584110444266E-3,{"$f":"G77/mito_total_patients","v":2.6954177897574125E-3},null,"beta",{"$f":"1","v":1},{"$f":"mito_total_patients-G77","v":370},null,"Incidence of diarrhoea for patients with Mitoxantrone","Bono et al., 2010, Table 4"]
["Fatigue ",2.9649595687331536E-2,3.4194264289097775E-2,{"$f":"G78/mito_total_patients","v":2.9649595687331536E-2},null,"beta",{"$f":"11","v":11},{"$f":"mito_total_patients-G78","v":360},null,"Incidence of fatigue for patients with Mitoxantrone","Bono et al., 2010, Table 4"]
["Asthenia ",2.4258760107816711E-2,1.4935386318390535E-2,{"$f":"G79/mito_total_patients","v":2.4258760107816711E-2},null,"beta",{"$f":"9","v":9},{"$f":"mito_total_patients-G79","v":362},null,"Incidence of asthenia for patients with Mitoxantrone","Bono et al., 2010, Table 4"]
["Absolute value disutilities of adverse events for Cabazitaxel and Mitoxantrone"]
["Neutropenia",{"$f":"IF(Ind_PSA=0,D81,C81)","v":0.09},{"$f":"_xlfn.BETA.INV(RAND(),G81,H81)","v":9.0923820043352088E-2},{"$f":"ABS(-0.09)","v":0.09},1.5699999999999999E-2,"beta",{"$f":"D81*((D81*(1-D81))/E81^2-1)","v":29.813850054768956},{"$f":"(1-D81)*((D81*(1-D81))/(E81^2)-1)","v":301.45115055377505},null,"Disutility of neutropenia for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Febrile neutropenia ",0.12,9.7148779991775666E-2,{"$f":"ABS(-0.12)","v":0.12},2.0899999999999998E-2,"beta",28.890324855200205,211.86238227146819,null,"Disutility of febrile neutropenia for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Leukopenia ",0.09,8.4588798156112976E-2,{"$f":"ABS(-0.09)","v":0.09},1.5699999999999999E-2,"beta",29.813850054768956,301.45115055377505,null,"Disutility of leukopenia for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Anaemia ",0.125,0.14440683321473879,{"$f":"ABS(-0.125)","v":0.125},2.1700000000000001E-2,"beta",28.909116247955996,202.36381373569196,null,"Disutility of leukopenia for patients with Cabazitaxel and Mitoxantrone of anaemia for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Diarrhoea ",{"$f":"IF(Ind_PSA=0,D85,C85)","v":4.7E-2},5.6680929353277287E-2,{"$f":"ABS(-0.047)","v":4.7E-2},8.2000000000000007E-3,"beta",31.26140273646638,633.8748256989885,null,"Disutility of leukopenia for patients with Cabazitaxel and Mitoxantrone of diarrhoea for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Fatigue ",9.4E-2,0.11294110668025437,{"$f":"ABS(-0.094)","v":9.4E-2},1.6299999999999999E-2,"beta",30.036663555271186,289.50231043697551,null,"Disutility of leukopenia for patients with Cabazitaxel and Mitoxantroneof fatigue for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Asthenia ",9.4E-2,9.3354892847624771E-2,{"$f":"ABS(-0.094)","v":9.4E-2},1.6299999999999999E-2,"beta",30.036663555271186,289.50231043697551,null,"Disutility of leukopenia for patients with Cabazitaxel and Mitoxantrone of asthenia for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Average duration of adverse events (in days) for Cabazitaxel and Mitoxantrone"]
["Percentage used for SE calculation average duration of adverse events",{"$f":"IF(Ind_PSA=0,D89,C89)","v":0.1},{"$f":"D89","v":0.1},0.1,null,"fixed",null,null,null,"Assumed percentage used for SE calculation of average duration of adverse events","Based on own reasoning."]
["Neutropenia",{"$f":"IF(Ind_PSA=0,D90,C90)","v":1.9},{"$f":"GAMMAINV(RAND(),G90,H90)","v":1.8501763736519852},1.9,{"$f":"D90*perc_SE_duration_AE","v":0.19},"gamma",{"$f":"(D90^2)/(E90^2)","v":100},{"$f":"(E90^2)/(D90)","v":1.9E-2},null,"Duration (days) of neutropenia for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Febrile neutropenia ",{"$f":"IF(Ind_PSA=0,D91,C91)","v":6.2},6.750782110480797,6.2,0.62000000000000011,"gamma",{"$f":"(D91^2)/(E91^2)","v":99.999999999999972},{"$f":"(E91^2)/(D91)","v":6.200000000000002E-2},null,"Duration (days) of febrile neutropenia for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Leukopenia ",11.1,9.8305711208016149,11.1,1.1100000000000001,"gamma",{"$f":"(D92^2)/(E92^2)","v":99.999999999999986},{"$f":"(E92^2)/(D92)","v":0.11100000000000002},null,"Duration (days) of leukopenia for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Anaemia ",25.4,25.478099786926137,25.4,{"$f":"D93*perc_SE_duration_AE","v":2.54},"gamma",100,0.254,null,"Duration (days) of anaemia for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Diarrhoea ",8,7.7833279898670282,8,0.8,"gamma",99.999999999999986,8.0000000000000016E-2,null,"Duration (days) of diarrhoea for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Fatigue ",19.3,21.081377980371151,19.3,1.9300000000000002,"gamma",99.999999999999986,0.19300000000000003,null,"Duration (days) of fatigue for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Asthenia ",{"$f":"IF(Ind_PSA=0,D96,C96)","v":13.3},14.207516036978731,13.3,1.33,"gamma",100,0.13300000000000001,null,"Duration (days) of asthenia for patients with Cabazitaxel and Mitoxantrone","NICE TA391, ERG report, Table 30"]
["Unit cost of adverse events (in £) for Cabazitaxel and Mitoxantrone"]
["Percentage used for SE calculation for unit costs of adverse events",{"$f":"IF(Ind_PSA=0,D98,C98)","v":0.2},{"$f":"D98","v":0.2},0.2,null,"fixed",null,null,null,"Assumed percentage used for SE calculation of unit costs of adverse events","The assumption is based on information from: National Cost Collection 2023/2024"]
["Neutropenia",389,{"$f":"GAMMAINV(RAND(),G99,H99)","v":283.35525481654878},389,{"$f":"perc_SE_unitcosts_AE*D99","v":77.800000000000011},"gamma",{"$f":"(D99^2)/(E99^2)","v":24.999999999999993},{"$f":"(E99^2)/(D99)","v":15.560000000000006},null,"Treatment costs (in £) of neutropenia","National Cost Collection 2023/2024: sheet Admitted Patient Care (APC); weighted average of SA35A-E; Day Case; round value  "]
["Febrile neutropenia (2016)",2545,1981.451416488522,2545,{"$f":"perc_SE_unitcosts_AE*D100","v":509},"gamma",25,101.8,null,"Treatment costs (in £) of febrile neutropenia","Talbot at al. 2017 (2016 price); (SD: £2458); source is for costs of neutropenic sepsis, assumed to be the same as febrile neutropenia "]
["Leukopenia",389,385.00265013211987,389,77.800000000000011,"gamma",24.999999999999993,15.560000000000006,null,"Treatment costs (in £) of leukopenia","National Cost Collection 2023/2024: weighted average of SA35A-E; Day Case "]
["Anaemia",393,410.52771252983325,393,78.600000000000009,"gamma",24.999999999999996,15.720000000000002,null,"Treatment costs (in £) of anaemia","National Cost Collection 2023/2024: weighted average of: SA01G-K, SA03G-H, SA04G-L, SA05G-J; Day Case "]
["Diarrhoea",511,548.12314553870658,511,102.2,"gamma",25,20.440000000000001,null,"Treatment costs (in £) of diarrhoea","National Cost Collection 2023/2024: weighted average of: FD10J-M; Day Case "]
["Fatigue",520,642.08905755305636,520,104,"gamma",25,20.8,null,"Treatment costs (in £) of fatigue","National Cost Collection 2023/2024: sheet Admitted Patient Care (APC); weighted average calculated from: SA01G-K; Day Case, round value "]
["Asthenia",520,513.10123069469012,520,104,"gamma",25,20.8,null,"Treatment costs (in £) of asthenia","National Cost Collection 2023/2024: sheet Admitted Patient Care (APC); weighted average calculated from: SA01G-K; Day Case, round value "]
[]
["Drug acquisition costs in SD "]
["Quantity for Cabazitaxel",{"$f":"IF(Ind_PSA=0,D108,C108)","v":1621},{"$f":"D108","v":1621},1621,null,"fixed",null,null,null,"The number of prescriptions for Cabazitaxel - input variable used for SE calculation of vial costs for Cabazitaxel","Emit National Database: 1 july 2024- 30 june 2025: NPC code= DXA015"]
["Quantity for Mitoxantrone",{"$f":"IF(Ind_PSA=0,D109,C109)","v":797},{"$f":"D109","v":797},797,null,"fixed",null,null,null,"The number of prescriptions for Mitoxantrone - input variable used for SE calculation of vial costs for Mitoxantrone","Emit National Database: 1 july 2024- 30 june 2025: NPC code= DHA044"]
["Standard deviation for Cabazitaxel",{"$f":"IF(Ind_PSA=0,D110,C110)","v":43.75},{"$f":"D110","v":43.75},43.75,null,"fixed",null,null,null,"The standard deviation of Cabazitaxel - input variable used for SE calculation of vial costs for Cabazitaxel","Emit National Database: 1 july 2024- 30 june 2025: NPC code= DXA015"]
["Standard deviation for Mitoxantrone",{"$f":"IF(Ind_PSA=0,D111,C111)","v":22.78},{"$f":"D111","v":22.78},22.78,null,"fixed",null,null,null,"The standard deviation of Mitoxantrone - input variable used for SE calculation of vial costs for Mitoxantrone","Emit National Database: 1 july 2024- 30 june 2025: NPC code= DHA044"]
["Vial acquisition costs for Cabazitaxel",{"$f":"IF(Ind_PSA=0,D112,C112)","v":151.07},{"$f":"GAMMAINV(RAND(),G112,H112)","v":149.86461783093876},151.07,{"$f":"SD_caba/SQRT(Quantity_caba)","v":1.0866421574212042},"gamma",{"$f":"(D112^2)/(E112^2)","v":19327.841636780409},{"$f":"(E112^2)/(D112)","v":7.8161857303568495E-3},null,"Vial acquisition costs (in £) for Cabazitaxel","Emit National Database: 1 july 2024- 30 june 2025: NPC code= DXA015"]
["Vial acquisition costs for Mitoxantrone",94.72,{"$f":"GAMMAINV(RAND(),G113,H113)","v":94.681751694715942},94.72,{"$f":"SD_mito/SQRT(Quantity_mito)","v":0.80690899920545278},"gamma",{"$f":"(D113^2)/(E113^2)","v":13779.525431254096},{"$f":"(E113^2)/(D113)","v":6.8739667757468899E-3},null,"Vial acquisition costs (in £) for Mitoxantrone","Emit National Database: 1 july 2024- 30 june 2025: NPC code= DHA044"]
["Dosage (mg) per m2 for Cabazitaxel",25,{"$f":"D114","v":25},25,null,"fixed",null,null,null,"Dosage (mg) per m2 for Cabizitaxel","Bono et al., 2010"]
["Dosage (mg) per m2 for Mitoxantrone",12,{"$f":"D115","v":12},12,null,"fixed",null,null,null,"Dosage (mg) per m2 for Mitoxantrone ","Bono et al., 2010"]
["Dosage(mg) per vial for Cabazitaxel",60,{"$f":"D116","v":60},60,null,"fixed",null,null,null,"Dosage(mg) per 1.5ml vial for Cabazitaxel","Emit National Database: 1 july 2024- 30 june 2025: NPC code= DXA015"]
["Dosage(mg) per vial for Mitoxantrone",20,{"$f":"D117","v":20},20,null,"fixed",null,null,null,"Dosage(mg) per 10ml vial for Mitoxantrone","Emit National Database: 1 july 2024- 30 june 2025: NPC code= DHA044"]
[]
["Percentage of patients receiving premedication (in decimals) in SD"]
["Antihistamine for Cabazitaxel",{"$f":"IF(Ind_PSA=0,D120,C120)","v":1},{"$f":"D120","v":1},1,null,"fixed",null,null,null,"Prevalence for antihistamine for Cabazitaxel","Source for this wasn't given in the instruction assignment 3. We got the value from Table 5 of the instructions assignment 3 word file."]
["Antihistamine for Mitoxantrone",0.09,{"$f":"_xlfn.BETA.INV(RAND(),G121,H121)","v":9.2181350380224347E-2},0.09,null,"beta",{"$f":"D121*mito_total_patients","v":33.39},{"$f":"mito_total_patients-G121","v":337.61},null,"Prevalence for antihistamine for Mitoxantrone","Source for this wasn't given in the instruction assignment 3. We got the value from Table 5 of the instructions assignment 3 word file."]
["H2 antagonist for Cabazitaxel",1,{"$f":"D122","v":1},1,null,"fixed",null,null,null,"Prevalence for H2 antagonist for Cabazitaxel","Source for this wasn't given in the instruction assignment 3. We got the value from Table 5 of the instructions assignment 3 word file."]
["H2 antagonist for Mitoxantrone",0.25,{"$f":"_xlfn.BETA.INV(RAND(),G123,H123)","v":0.26468782768882237},0.25,null,"beta",{"$f":"D123*mito_total_patients","v":92.75},{"$f":"mito_total_patients-G123","v":278.25},null,"Prevalence for H2 antagonist for Mitoxantrone","Source for this wasn't given in the instruction assignment 3. We got the value from Table 5 of the instructions assignment 3 word file."]
["Anti-emetics for Cabazitaxel",1,{"$f":"D124","v":1},1,null,"fixed",null,null,null,"Prevalence for anti-emetics for Cabazitaxel","Source for this wasn't given in the instruction assignment 3. We got the value from Table 5 of the instructions assignment 3 word file."]
["Anti-emetics for Mitoxantrone",1,1,1,null,"fixed",null,null,null,"Prevalence for anti-emetics for Mitoxantrone","Source for this wasn't given in the instruction assignment 3. We got the value from Table 5 of the instructions assignment 3 word file."]
["Corticosteroids for Cabazitaxel",1,{"$f":"D126","v":1},1,null,"fixed",null,null,null,"Prevalence for Corticosteroids for Cabazitaxel","Source for this wasn't given in the instruction assignment 3. We got the value from Table 5 of the instructions assignment 3 word file."]
["Corticosteroids for Mitoxantrone",0.56000000000000005,{"$f":"_xlfn.BETA.INV(RAND(),G127,H127)","v":0.55537254257001023},0.56000000000000005,null,"beta",{"$f":"D127*mito_total_patients","v":207.76000000000002},{"$f":"mito_total_patients-G127","v":163.23999999999998},null,"Prevalence for Corticosteroids for Mitoxantrone","Source for this wasn't given in the instruction assignment 3. We got the value from Table 5 of the instructions assignment 3 word file."]
["Prophylaxis for Cabazitaxel",0.25,{"$f":"_xlfn.BETA.INV(RAND(),G128,H128)","v":0.25744478443713181},0.25,null,"beta",{"$f":"D128*Caba_total_patients","v":92.75},{"$f":"Caba_total_patients-G128","v":278.25},null,"Prevalence for prophylaxis for Cabazitaxel","Source for this wasn't given in the instruction assignment 3. We got the value from Table 5 of the instructions assignment 3 word file."]
["Prophylaxis for Mitoxantrone",0.1,{"$f":"_xlfn.BETA.INV(RAND(),G129,H129)","v":6.7385667063860899E-2},0.1,null,"beta",{"$f":"D129*mito_total_patients","v":37.1},{"$f":"mito_total_patients-G129","v":333.9},null,"Prevalence for prophylaxis for Mitoxantrone","Source for this wasn't given in the instruction assignment 3. We got the value from Table 5 of the instructions assignment 3 word file."]
["Premedication drugs and dosing other than prophylaxis in SD for Cabazitaxel and Mitoxantrone"]
["Quantity for antihistamine",{"$f":"IF(Ind_PSA=0,D131,C131)","v":171172},{"$f":"D131","v":171172},171172,null,"fixed",null,null,null,"The number of prescriptions for antihistamine - input variable used for SE calculation of costs per pack for antihistamine","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Chlorphenime"]
["Quantity for H2 antagonist",1718,1718,1718,null,"fixed",null,null,null,"The number of prescriptions for H2 antagonist - input variable used for SE calculation of costs per pack for h2 antagonist","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Cimetidine"]
["Quantity for anti-emetics",{"$f":"IF(Ind_PSA=0,D133,C133)","v":225101},225101,225101,null,"fixed",null,null,null,"The number of prescriptions for anti-emetics - input variable used for SE calculation of costs per pack for anti-emetics","Emit National Database: 1 july 2024- 30 june 2025: NPC code = DDF029 "]
["Quantity for corticosteroids",{"$f":"IF(Ind_PSA=0,D134,C134)","v":4435},4435,4435,null,"fixed",null,null,null,"The number of prescriptions for corticosteroids - input variable used for SE calculation of costs per pack for corticosteroids","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Dexamethasone"]
["Standard deviation for antihistamine",0.21,0.21,0.21,null,"fixed",null,null,null,"The standard deviation of antihistamine - input variable used for SE calculation of costs per pack for antihistamine","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Chlorphenamine"]
["Standard deviation for H2 antagonist",1.71,1.71,1.71,null,"fixed",null,null,null,"The standard deviation of H2 antagonist - input variable used for SE calculation of costs per pack for h2 antagonist","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Cimetidine"]
["Standard deviation for anti-emetics",1.1100000000000001,1.1100000000000001,1.1100000000000001,null,"fixed",null,null,null,"The standard deviation of anti-emetics - input variable used for SE calculation of costs per pack for anti-emetics","Emit National Database: 1 july 2024- 30 june 2025: NPC code = DDF029 "]
["Standard deviation for corticosteroids",3.6,{"$f":"D138","v":3.6},3.6,null,"fixed",null,null,null,"The standard deviation of corticosteroids - input variable used for SE calculation of costs per pack for corticosteroids","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Dexamethasone"]
["Antihistamine (Chlorphenamine) costs per pack",{"$f":"IF(Ind_PSA=0,D139,C139)","v":0.38},{"$f":"GAMMAINV(RAND(),G139,H139)","v":0.37997861112826875},0.38,{"$f":"SD_antihistamine/SQRT(quantity_antihistamine)","v":5.075781660065714E-4},"gamma",{"$f":"(D139^2)/(E139^2)","v":560481.56009070284},{"$f":"(E139^2)/(D139)","v":6.7798840685945944E-7},null,"Antihistamine costs (in £) per pack","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Chlorphenime"]
["H2 antagonist (Cimetidine) costs per pack",5.41,{"$f":"GAMMAINV(RAND(),G140,H140)","v":5.3511215487506325},5.41,{"$f":"SD_h2_antagonist/SQRT(quantity_h2_antagonist)","v":4.1255754175864058E-2},"gamma",{"$f":"(D140^2)/(E140^2)","v":17195.922095687562},{"$f":"(E140^2)/(D140)","v":3.1460947368194543E-4},null,"H2 antagonist costs (in £) per pack","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Cimetidine"]
["Anti-emetics (Ondansetron) costs per pack",{"$f":"IF(Ind_PSA=0,D141,C141)","v":3.5},3.496925314183517,3.5,{"$f":"SD_anti_emetics/SQRT(quantity_anti_emetics)","v":2.3395604260993377E-3},"gamma",2238038.5114844572,1.5638694249628899E-6,null,"Anti-emetics costs (in £) per pack","Emit National Database: 1 july 2024- 30 june 2025: NPC code = DDF029 "]
["Corticosteroids (Dexamethasone) costs per pack",39.6,39.49967947765689,39.6,{"$f":"SD_corticosteroids/SQRT(quantity_corticosteroids)","v":5.4057466603635404E-2},"gamma",536635,7.3793174131392848E-5,null,"Corticosteroids costs (in £) per pack","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Dexamethasone"]
["Antihistamine (Chlorphenamine) pack size",28,{"$f":"D143","v":28},28,null,"fixed",null,null,null,"Antihistamine pack size","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Chlorphenamine"]
["H2 antagonist (Cimetidine) pack size",60,60,60,null,"fixed",null,null,null,"H2 antagonist pack size","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Cimetidine"]
["Anti-emetics (Ondansetron) pack size",10,10,10,null,"fixed",null,null,null,"Anti-emetics pack size","Emit National Database: 1 july 2024- 30 june 2025: NPC code = DDF029 "]
["Corticosteroids (Dexamethasone) pack size",50,50,50,null,"fixed",null,null,null,"Corticosteroids pack size","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Dexamethasone"]
["Antihistamine (Chlorphenamine) dosing per cycle",1,1,1,null,"fixed",null,null,null,"Antihistamine dosing per cycle","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Chlorphenamine"]
["H2 antagonist (Cimetidine) dosing per cycle",1,1,1,null,"fixed",null,null,null,"H2 antagonist dosing per cycle","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Cimetidine"]
["Anti-emetics (Ondansetron) dosing per cycle",1,1,1,null,"fixed",null,null,null,"Anti-emetics dosing per cycle","Emit National Database: 1 july 2024- 30 june 2025: NPC code = DDF029 "]
["Corticosteroids (Dexamethasone) dosing per cycle",1,{"$f":"D150","v":1},1,null,"fixed",null,null,null,"Corticosteroids dosing per cycle","Emit National Database: 1 july 2024- 30 june 2025: Name & Pack Size = Dexamethasone"]
["Premedication drugs and dosing prophylaxis in SD for Cabazitaxel and Mitoxantrone"]
["Percentage used for SE calculation for unit costs of prophylaxis",{"$f":"IF(Ind_PSA=0,D152,C152)","v":0.1},{"$f":"D152","v":0.1},0.1,null,"fixed",null,null,null,"Assumed percentage used for SE calculation of unit cost of prophylaxis","Based on own reasoning."]
["Prophylaxis (G-SCF) dosage (mg/kg)",{"$f":"IF(Ind_PSA=0,D153,C153)","v":5.0000000000000001E-3},{"$f":"D153","v":5.0000000000000001E-3},5.0000000000000001E-3,null,"fixed",null,null,null,"Prophylaxis dosage (mg/kg)","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table 6 of the instructions assignment 3 word file."]
["Prophylaxis (G-SCF) unit costs per mg (2020/2021)",{"$f":"IF(Ind_PSA=0,D154,C154)","v":193.88},{"$f":"GAMMAINV(RAND(),G154,H154)","v":222.20257683743532},193.88,{"$f":"D154*perc_SE_unitcosts_prophylaxis","v":19.388000000000002},"gamma",{"$f":"(D154^2)/(E154^2)","v":99.999999999999972},{"$f":"(E154^2)/(D154)","v":1.9388000000000003},null,"Prophylaxis unit costs (in £) per mg","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table 6 of the instructions assignment 3 word file."]
["Prophylaxis (G-SCF) dosing per cycle (in days)",{"$f":"IF(Ind_PSA=0,D155,C155)","v":4.0999999999999996},{"$f":"D155","v":4.0999999999999996},4.0999999999999996,null,"fixed",null,null,null,"Prophylaxis dosing per cycle","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table 6 of the instructions assignment 3 word file."]
[]
["Concomitant medication costs in SD and PD for Cabazitaxel and Mitoxantrone"]
["Percentage used for SE calculation for LHRH cycle costs",{"$f":"IF(Ind_PSA=0,D158,C158)","v":0.2},{"$f":"D158","v":0.2},0.2,null,"fixed",null,null,null,"Assumed percentage used for SE calculation for LHRH cycle costs","Based on own reasoning."]
["Quantity for prednisolone ",{"$f":"IF(Ind_PSA=0,D159,C159)","v":2320376},{"$f":"D159","v":2320376},2320376,null,"fixed",null,null,null,"The number of prescriptions for prednisolone","Emit National Database: 1 july 2024- 30 june 2025: NPC code=DFN040"]
["Standard deviation prednisolone costs",0.06,0.06,0.06,null,"fixed",null,null,null,"The standard deviation of prednisolone","Emit National Database: 1 july 2024- 30 june 2025: NPC code=DFN040"]
["Prednisolone costs per pack",0.31,{"$f":"GAMMAINV(RAND(),G161,H161)","v":0.31003590805572867},0.31,{"$f":"SD_prednisolone/SQRT(Quantity_prednisolone)","v":3.9388738141209291E-5},"gamma",{"$f":"(D161^2)/(E161^2)","v":61941148.222222239},{"$f":"(E161^2)/(D161)","v":5.0047506205056633E-9},null,"Prednisolone costs (in £) per pack","Emit National Database: 1 july 2024- 30 june 2025: NPC code=DFN040"]
["Prednisolone pack size",28,{"$f":"D162","v":28},28,null,"fixed",null,null,null,"Prednisolone pack size","Emit National Database: 1 july 2024- 30 june 2025: NPC code=DFN040"]
["Prednisolone dosage (in tablets) per day",2,{"$f":"D163","v":2},2,null,"fixed",null,null,null,"Prednisolone dosage (per tablet) per day","Emit National Database: 1 july 2024- 30 june 2025: NPC code=DFN040"]
["LHRH (50% leuroprorelin and 50% goserelin) cycle cost",77.31,{"$f":"GAMMAINV(RAND(),G164,H164)","v":79.394060030107127},77.31,{"$f":"perc_SE_LHRH_cyclecosts*D164","v":15.462000000000002},"gamma",{"$f":"(D164^2)/(E164^2)","v":24.999999999999996},{"$f":"(E164^2)/(D164)","v":3.0924000000000005},null,"LHRH (50% leuroprorelin and 50% goserelin) cycle cost","NICE submission Relugolix for hormone-sensitive prostate cancer (NICE TA995) published October 2024"]
[]
["Chemotherapy administration cost in SD and PD for Cabazitaxel and Mitoxantrone"]
["Percentage used for SE calculation for infusion with chemotherapy costs per chemo administration",{"$f":"IF(Ind_PSA=0,D167,C167)","v":0.2},{"$f":"D167","v":0.2},0.2,null,"fixed",null,null,null,"Assumed percentage used for SE calculation for infusion with chemotherapy costs per chemo administration","The assumption is based on information provided in the assignment on page 8."]
["Percentage used for SE calculation for pharmacist hourly cost",0.1,0.1,0.1,null,"fixed",null,null,null,"Assumed percentage used for SE calculation for pharmacist hourly cost","The assumption is based on information from: PSSRU, 2014"]
["Percentage used for SE calculation for preparation time pharmacist per administration (cabazitaxel and mitoxantrone)",0.05,{"$f":"D169","v":0.05},0.05,null,"fixed",null,null,null,"Assumed percentage used for SE calculation for preparation time pharmacist per administration (cabazitaxel and mitoxantrone)","Based on own reasoning."]
["Infusion with chemotherapy costs per chemo administration (outpatient visit) ",430,{"$f":"GAMMAINV(RAND(),G170,H170)","v":510.57250710678329},430,{"$f":"perc_SE_unitcosts_chemoinfusion*D170","v":86},"gamma",{"$f":"(D170^2)/(E170^2)","v":25},{"$f":"(E170^2)/(D170)","v":17.2},null,"The costs (in £) for infusion with chemotherapy (includes chair use, nurse time, consumables etc.), per chemo administration. This is per cycle, because chemo is administered once per cycle","Based on National Cost Collection 2023/2024; 'currency code' SB15Z, 'Total HRG' sheet (NICE TA391, Table 64)"]
["Pharmacist hourly cost",50,{"$f":"GAMMAINV(RAND(),G171,H171)","v":46.219732376890065},50,{"$f":"perc_SE_unitcosts_hourlycost_pharmacist*D171","v":5},"gamma",{"$f":"(D171^2)/(E171^2)","v":100},0.5,null,"The costs (in £) of the pharmacist's time to prepare the chemotherapy prior to administration","NICE TA391, Table 64; Hospital-based scientific and professional staff; Band 6"]
["Preparation time pharmacist per administration (in minutes) for Cabazitaxel",15,{"$f":"GAMMAINV(RAND(),G172,H172)","v":16.841072077252576},15,{"$f":"perc_SE_preptime_pharmacist*D172","v":0.75},"gamma",400,3.7499999999999999E-2,null,"The preparation time of Cabazitaxel by the pharmacist","De Bono, et al. 2010"]
["Preparation time pharmacist per administration (in minutes) for Mitoxantrone",60,{"$f":"GAMMAINV(RAND(),G173,H173)","v":59.080535311681388},60,{"$f":"perc_SE_preptime_pharmacist*D173","v":3},"gamma",400,0.15,null,"The preparation time of Mitoxantrone by the pharmacist","De Bono, et al. 2010"]
[]
["Health care resource use in SD for Cabazitaxel and Mitoxantrone"]
["Clinical oncologist resource use estimate (per 3 months)",{"$f":"IF(Ind_PSA=0,D176,C176)","v":4.3},{"$f":"GAMMAINV(RAND(),G176,H176)","v":3.9461706514543367},4.3,0.35799999999999998,"gamma",{"$f":"(D176^2)/(E176^2)","v":144.26828126462968},{"$f":"(E176^2)/(D176)","v":2.9805581395348838E-2},null,"The frequency of use for the clinical oncologist in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["Urologist (outpatient care) resource use estimate (per 3 months) ",7.0000000000000007E-2,{"$f":"GAMMAINV(RAND(),G177,H177)","v":6.8498295551628133E-2},7.0000000000000007E-2,6.0000000000000001E-3,"gamma",{"$f":"(D177^2)/(E177^2)","v":136.11111111111111},{"$f":"(E177^2)/(D177)","v":5.142857142857143E-4},null,"The frequency of use for the urologist in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["Oncology ward (inpatient care) resource use estimate (per 3 months) ",0.03,2.8410116487160148E-2,0.03,3.0000000000000001E-3,"gamma",{"$f":"(D178^2)/(E178^2)","v":100},3.0000000000000003E-4,null,"The frequency of use for the oncology ward in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["General ward (inpatient care) resource use estimate (per 3 months) ",0.04,4.0914977859443834E-2,0.04,3.0000000000000001E-3,"gamma",177.77777777777777,2.2499999999999999E-4,null,"The frequency of use for the general ward in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["CT scan resource use estimate (per 3 months) ",0.15,0.14388591063595524,0.15,1.2999999999999999E-2,"gamma",133.1360946745562,1.1266666666666667E-3,null,"The frequency of use for CT scan in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["MRI resource use estimate (per 3 months) ",0.04,4.0554481483748517E-2,0.04,3.0000000000000001E-3,"gamma",177.77777777777777,2.2499999999999999E-4,null,"The frequency of use for MRI in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["Bone scan resource use estimate (per 3 months) ",0.09,0.10330550318834532,0.09,8.0000000000000002E-3,"gamma",126.5625,7.1111111111111115E-4,null,"The frequency of use for bone scan in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["Ultrasound resource use estimate (per 3 months) ",0.04,4.1031662849537472E-2,0.04,3.0000000000000001E-3,"gamma",177.77777777777777,2.2499999999999999E-4,null,"The frequency of use for the ultrasound in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["Conventional x-ray resource use estimate (per 3 months) ",0.13,0.11979603974268753,0.13,1.0999999999999999E-2,"gamma",139.66942148760333,9.3076923076923068E-4,null,"The frequency of use for the conventional x-ray in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["Complete blood count resource use estimate (per 3 months) ",4.96,5.0408099885931055,4.96,0.41299999999999998,"gamma",144.23253932426178,3.4388911290322573E-2,null,"The frequency of use for complete blood count in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["Chemistry panel resource use estimate (per 3 months) ",6.06,6.1845267487653039,6.06,0.505,"gamma",144,4.2083333333333334E-2,null,"The frequency of use for the chemistry panel in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["Liver function test resource use estimate (per 3 months) ",2,2.0877600826472107,2,0.16700000000000001,"gamma",143.42572340349238,1.3944500000000002E-2,null,"The frequency of use for liver function test in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["PSA resource use estimate (per 3 months) ",2,1.973281327526514,2,0.16700000000000001,"gamma",143.42572340349238,1.3944500000000002E-2,null,"The frequency of use for PSA in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["ECG resource use estimate (per 3 months) ",{"$f":"IF(Ind_PSA=0,D189,C189)","v":1},0.96283335660770608,1,8.3000000000000004E-2,"gamma",145.15894904920887,6.889000000000001E-3,null,"The frequency of use for ECG in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
["Echocardiography resource use estimate (per 3 months) ",0,{"$f":"D190","v":0},0,0,"fixed",null,null,null,"The frequency of use for echocardiography in the stable disease health state, per 3 months","Company submission from NICE TA391, Table 63 (UK observational study)"]
[]
["Oncology ward average length of stay inpatient care (days) per visit",{"$f":"IF(Ind_PSA=0,D192,C192)","v":8.17},9.8190375604837499,8.17,0.68100000000000005,"gamma",143.9295240436345,5.6763892288861702E-2,null,"The average length of stay inpatient care (days) per visit for oncology ward in the stable disease health state","Company submission from NICE TA391, Table 63 (UK observational study)"]
["General ward average length of stay inpatient care (days) per visit",{"$f":"IF(Ind_PSA=0,D193,C193)","v":8.17},10.079008399493052,8.17,0.68100000000000005,"gamma",143.9295240436345,5.6763892288861702E-2,null,"The average length of stay inpatient care (days) per visit for general ward in the stable disease health state","Company submission from NICE TA391, Table 63 (UK observational study)"]
["Costs healthcare resources in SD for Cabazitaxel and Mitoxantrone"]
["Percentage used for SE calculation for the healthcare resources costs in SD",{"$f":"IF(Ind_PSA=0,D195,C195)","v":0.2},{"$f":"D195","v":0.2},0.2,null,"fixed",null,null,null,"Assumed percentage used for SE calculation for the healthcare resources costs in SD","The assumption is based on information from: National Cost Collection 2023/2024"]
["Clinical oncologist resource use unit cost (in £) per visit",{"$f":"IF(Ind_PSA=0,D196,C196)","v":193},{"$f":"GAMMAINV(RAND(),G196,H196)","v":164.24887533356278},193,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D196","v":38.6},"gamma",{"$f":"(D196^2)/(E196^2)","v":25},{"$f":"(E196^2)/(D196)","v":7.72},null,"Health care resource use unit cost (in £) for the clinical oncology per visit"," National Cost Collection 2023/2024: Summary: Outpatient Attendance:  Currency: WF01A: Non-Admitted Face-to-Face Attendance, Follow-up; Service code 370: Medical Oncology Service – Consultant led  "]
["Urologist (outpatient care) resource use unit cost (in £) per visit",163,143.15057063229159,163,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D197","v":32.6},"gamma",{"$f":"(D197^2)/(E197^2)","v":25},{"$f":"(E197^2)/(D197)","v":6.52},null,"Health care resource use unit cost (in £) for the urologist per visit"," National Cost Collection 2023/2024: Summary: Outpatient Attendance:   Consultant-led; WF01A: Non-Admitted Face-to-Face Attendance, Follow-up; Service code 101: Urology "]
["Oncology ward (inpatient care) resource use unit cost (in £) per 24h",824,1019.3432489340107,824,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D198","v":164.8},"gamma",{"$f":"(D198^2)/(E198^2)","v":24.999999999999996},32.960000000000008,null,"Health care resource use unit cost (in £) for the oncology ward per 24h"," National Cost Collection 2023/2024: Summary: HRG Costs: Non-elective Inpatient Short Stay; Weighted average of currency codes LB06H, LB06J, LB06K, LB06L, LB06M, LB06N, LB06P, LB06Q, LB06R, LB06S "]
["General ward (inpatient care) resource use unit cost (in £) per 24",824,728.03770004029354,824,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D199","v":164.8},"gamma",24.999999999999996,32.960000000000008,null,"Health care resource use unit cost (in £) for the general ward per 24h"," National Cost Collection 2023/2024: Summary: HRG Costs: Non-elective Inpatient Short Stay; Weighted average of currency codes LB06H, LB06J, LB06K, LB06L, LB06M, LB06N, LB06P, LB06Q, LB06R, LB06S "]
["Urology ward (inpatient care) resource use unit cost (in £) per 24",824,{"$f":"GAMMAINV(RAND(),G200,H200)","v":824.80272257934098},824,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D200","v":164.8},"gamma",24.999999999999996,32.960000000000008,null,"Health care resource use unit cost (in £) for the urology ward per 24h"," National Cost Collection 2023/2024: Summary: HRG Costs: Non-elective Inpatient Short Stay; Weighted average of currency codes LB06H, LB06J, LB06K, LB06L, LB06M, LB06N, LB06P, LB06Q, LB06R, LB06S "]
["CT scan resource use unit cost (in £) per scan",142,149.72812554861733,142,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D201","v":28.400000000000002},"gamma",24.999999999999993,5.6800000000000015,null,"Health care resource use unit cost (in £) for the CT scan per scan"," National Cost Collection 2023/2024: Total HRGs; RD22Z: Computerised Tomography Scan, one area, pre and post contrast, Total "]
["MRI resource use unit cost (in £) per scan",{"$f":"IF(Ind_PSA=0,D202,C202)","v":232},228.02087631278644,232,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D202","v":46.400000000000006},"gamma",24.999999999999993,9.2800000000000029,null,"Health care resource use unit cost (in £) for the MRI per scan"," National Cost Collection 2023/2024: Total HRGs; RD03Z: Magnetic Resonance Imaging Scan of one area, with pre and post contrast, directly accessed"]
["Bone scan resource use unit cost (in £) per scan",{"$f":"IF(Ind_PSA=0,D203,C203)","v":271},321.01395733261518,271,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D203","v":54.2},"gamma",24.999999999999996,10.840000000000002,null,"Health care resource use unit cost (in £) for the bone scan per scan"," National Cost Collection 2023/2024: Total HRGs; RN15A: Nuclear Bone Scan of Two or Three Phases, 19 years and over, directly accessed"]
["Ultrasound resource use unit cost (in £) per scan",71,{"$f":"GAMMAINV(RAND(),G204,H204)","v":72.764099075480559},71,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D204","v":14.200000000000001},"gamma",24.999999999999993,2.8400000000000007,null,"Health care resource use unit cost (in £) for the ultrasound per scan"," National Cost Collection 2023/2024: Total HRGs; Weighted average of RD40Z, RD41Z, RD42Z, RD43Z, directly accessed "]
["Conventional x-ray resource use unit cost (in £) per scan",42,42.753007336974029,42,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D205","v":8.4},"gamma",25,1.6800000000000002,null,"Health care resource use unit cost (in £) for the conventional x-ray per scan"," National Cost Collection 2023/2024: Other Currencies; PF: Plain Film, directly accessed "]
["Complete blood count resource use unit cost (in £) per test",3,2.3369734939909108,3,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D206","v":0.60000000000000009},"gamma",24.999999999999993,0.12000000000000004,null,"Health care resource use unit cost (in £) for the complete blood count per test"," National Cost Collection 2023/2024: Directly Accessed Pathology Services; PATH05 - Haematology "]
["Chemistry panel resource use unit cost (in £) per test",2,1.5872741204813674,2,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D207","v":0.4},"gamma",24.999999999999996,8.0000000000000016E-2,null,"Health care resource use unit cost (in £) for the chemistry panel per test"," National Cost Collection 2023/2024: Directly Accessed Pathology Services; PATH02 – Clinical Chemistry "]
["Liver function test resource use unit cost (in £) per test",7,9.6698304482279003,7,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D208","v":1.4000000000000001},"gamma",24.999999999999996,0.28000000000000008,null,"Health care resource use unit cost (in £) for the liver function per test"," National Cost Collection 2023/2024: Directly Accessed Pathology Services; PATH08 - Phlebotomy "]
["PSA resource use unit cost (in £) per test",2,1.9560541211152407,2,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D209","v":0.4},"gamma",24.999999999999996,8.0000000000000016E-2,null,"Health care resource use unit cost (in £) for the PSA per test"," National Cost Collection 2023/2024: Directly Accessed Pathology Services; PATH02 – Clinical Chemistry "]
["ECG resource use unit cost (in £) per test",118,78.469565293981432,118,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D210","v":23.6},"gamma",25,4.7200000000000006,null,"Health care resource use unit cost (in £) for the ECG per test"," National Cost Collection 2023/2024: Total HRGs tab; EY51Z: Electrocardiogram Monitoring or Stress Testing, total "]
["Echocardiography resource use unit cost (in £) per test",116,120.76522378201743,116,{"$f":"perc_SE_healthcare_resourceuse_cost_SD*D211","v":23.200000000000003},"gamma",24.999999999999993,4.6400000000000015,null,"Health care resource use unit cost (in £) for the echocardiography per test"," National Cost Collection 2023/2024: Total HRGs; RD51A: Simple Echocardiogram, 19 years and over"]
[]
["Post-second-line chemotherapy costs in PD for Cabazitaxel and Mitoxantrone"]
[]
["Percentage used for SE calculation for the Docetaxel and Carbonplatin-based regimens cost per mg",{"$f":"IF(Ind_PSA=0,D215,C215)","v":0.1},{"$f":"D215","v":0.1},0.1,null,"fixed ",null,null,null,"Assumed percentage used for SE calculation for the Docetaxel and Carbonplatin-based regimens cost per mg","Based on own reasoning."]
["Docetaxel cost (in £) per mg",{"$f":"IF(Ind_PSA=0,D216,C216)","v":0.63},{"$f":"GAMMAINV(RAND(),G216,H216)","v":0.58300598949032967},0.63,{"$f":"perc_SD_Docetaxel_Carbonplatin*D216","v":6.3E-2},"gamma",{"$f":"(D216^2)/(E216^2)","v":100},{"$f":"(E216^2)/(D216)","v":6.3E-3},null,"Costs of docetaxel (in £) per mg","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table10 of the instructions assignment 3 word file."]
["Carboplatin-based regimens cost (in £) per mg",0.39,{"$f":"GAMMAINV(RAND(),G217,H217)","v":0.40640429552169755},0.39,{"$f":"perc_SD_Docetaxel_Carbonplatin*D217","v":3.9000000000000007E-2},"gamma",{"$f":"(D217^2)/(E217^2)","v":99.999999999999986},3.9000000000000011E-3,null,"Costs of carboplating-based regimens (in £) per mg","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table10 of the instructions assignment 3 word file."]
["Docetaxel dosage (mg) per m2",75,{"$f":"D218","v":75},75,null,"fixed",null,null,null,"The dose of docetaxel in mg/m2","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table10 of the instructions assignment 3 word file."]
["Carboplatin-based regimens dosage (mg) per m2",360,360,360,null,"fixed ",null,null,null,"The dose of carboplatin-based regimen in mg/m2","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table10 of the instructions assignment 3 word file."]
["Docetaxel dosing per cycle",1,1,1,null,"fixed",null,null,null,"The amount of times docetaxel is administered per cycle","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table10 of the instructions assignment 3 word file."]
["Carboplatin-based regimens dosing per cycle",1,1,1,null,"fixed",null,null,null,"The amount of times carboplatin-based regimen are administered per cycle","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table10 of the instructions assignment 3 word file."]
["Docetaxel max number of cycles",10,10,10,null,"fixed",null,null,null,"Max amount of cycles docetaxel is administered","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table10 of the instructions assignment 3 word file."]
["Carboplatin-based regimens max number of cycles",6,6,6,null,"fixed",null,null,null,"Max amount of cycles carboplatin-based regimen are administered","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table10 of the instructions assignment 3 word file."]
["Mitoxantrone max number of cycles",10,{"$f":"D224","v":10},10,null,"fixed",null,null,null,"Max amount of cycles mitoxantrone is administered","Bono et al., 2010 "]
["Number of patients receiving post-second-line chemotheraphy in PD for Cabazitaxel and Mitoxantrone"]
["Docetaxel",{"$f":"IF(Ind_PSA=0,D226,C226)","v":6},{"$f":"GAMMAINV(RAND(),D226,1)","v":11.389731043528426},6,null,"dirichlet",null,null,null,"The number of patients receiving the additional line docetaxel","The company submission from NICE TA391, Table 66 (UK observational study)"]
["Carboplatin-based regimes",{"$f":"IF(Ind_PSA=0,D227,C227)","v":3},{"$f":"GAMMAINV(RAND(),D227,1)","v":2.0469176589796385},3,null,"dirichlet",null,null,null,"The number of patients receiving the additional line carboplatin-based regimens","The company submission from NICE TA391, Table 66 (UK observational study)"]
["Mitoxantrone (only for Cabazitaxel patients)",{"$f":"IF(Ind_PSA=0,D228,C228)","v":2},{"$f":"GAMMAINV(RAND(),D228,1)","v":0.58415139349541911},2,null,"dirichlet",null,null,null,"The number of patients receiving the additional line mitoxantrone","The company submission from NICE TA391, Table 66 (UK observational study)"]
[]
["Number of patients in TROPIC study after progression in PD"]
["Total amount of patients who progressed",{"$f":"IF(Ind_PSA=0,D231,C231)","v":447},{"$f":"D231","v":447},447,null,"fixed",null,null,null,"Total number of patients in TROPIC study who progressed (including both Mitoxantrone and Cabazitaxel patients)","De Bono, et al. 2010, figure 1"]
["Proportions of patients provided with further chemotherapy in addition to best supportive care",{"$f":"IF(Ind_PSA=0,D232,C232)","v":0.5592841163310962},{"$f":"_xlfn.BETA.INV(RAND(),G232,H232)","v":0.57094014738444154},{"$f":"G232/(G232+H232)","v":0.5592841163310962},null,"beta",250,{"$f":"total_progressed_patients-G232","v":197},null,"Number of patients in TROPIC study who were provided with further chemotherapy in addition to best supportive care","Source for this wasn't given in the instruction assignment 3. We got the value from the text above table 10 of the instructions assignment 3 word file."]
[]
["Healthcare resource use in PD - Best supportive care only -  for Cabazitaxel and Mitoxantrone"]
["Urologist (outpatient care) resource use estimate (per 3 months) ",{"$f":"IF(Ind_PSA=0,D235,C235)","v":0.05},{"$f":"GAMMAINV(RAND(),G235,H235)","v":5.0620681261062339E-2},0.05,4.0000000000000001E-3,"gamma",{"$f":"(D235^2)/(E235^2)","v":156.25000000000003},{"$f":"(E235^2)/(D235)","v":3.1999999999999997E-4},null,"The frequency of use for the urologist in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK observational study)"]
["Oncology ward (inpatient care) resource use estimate (per 3 months) ",0.13,0.14961336648270238,0.13,1.0999999999999999E-2,"gamma",139.66942148760333,{"$f":"(E236^2)/(D236)","v":9.3076923076923068E-4},null,"The frequency of use for the oncology ward in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["General ward (inpatient care) resource use estimate (per 3 months) ",0.09,9.9803169203193071E-2,0.09,8.0000000000000002E-3,"gamma",126.5625,7.1111111111111115E-4,null,"The frequency of use for the general ward in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Urology ward (inpatient care) resource use estimate (per 3 months) ",0.02,2.0835339230724767E-2,0.02,2E-3,"gamma",100.00000000000001,1.9999999999999998E-4,null,"The frequency of use for the urology ward in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["CT scan resource use estimate (per 3 months) ",0.47,0.48278294822854706,0.47,3.9E-2,"gamma",145.23339907955292,3.2361702127659576E-3,null,"The frequency of use for CT scan in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["MRI resource use estimate (per 3 months) ",0.15,0.14069874035076599,0.15,1.2999999999999999E-2,"gamma",133.1360946745562,1.1266666666666667E-3,null,"The frequency of use for MRI in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Bone scan resource use estimate (per 3 months) ",0.14000000000000001,0.14666385341653707,0.14000000000000001,1.2E-2,"gamma",136.11111111111111,1.0285714285714286E-3,null,"The frequency of use for bone scan in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Ultrasound resource use estimate (per 3 months) ",0,{"$f":"D242","v":0},0,0,"fixed",null,null,null,"The frequency of use for the ultrasound in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Conventional x-ray resource use estimate (per 3 months) ",0.84,{"$f":"GAMMAINV(RAND(),G243,H243)","v":0.89110005229786482},0.84,7.0000000000000007E-2,"gamma",{"$f":"(D243^2)/(E243^2)","v":143.99999999999997},{"$f":"(E243^2)/(D243)","v":5.8333333333333345E-3},null,"The frequency of use for the conventional x-ray in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Complete blood count resource use estimate (per 3 months) ",{"$f":"IF(Ind_PSA=0,D244,C244)","v":4.12},{"$f":"GAMMAINV(RAND(),G244,H244)","v":4.1497892859431156},4.12,0.34300000000000003,"gamma",{"$f":"(D244^2)/(E244^2)","v":144.2800193796802},{"$f":"(E244^2)/(D244)","v":2.8555582524271848E-2},null,"The frequency of use for complete blood count in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Chemistry panel resource use estimate (per 3 months) ",3.89,{"$f":"GAMMAINV(RAND(),G245,H245)","v":3.1622614553205111},3.89,0.32400000000000001,"gamma",144.14818625209574,2.698611825192802E-2,null,"The frequency of use for the chemistry panel in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Liver function test resource use estimate (per 3 months) ",2,{"$f":"GAMMAINV(RAND(),G246,H246)","v":2.2271182007128072},2,0.16700000000000001,"gamma",143.42572340349238,1.3944500000000002E-2,null,"The frequency of use for liver function test in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["PSA resource use estimate (per 3 months) ",{"$f":"IF(Ind_PSA=0,D247,C247)","v":2},{"$f":"GAMMAINV(RAND(),G247,H247)","v":1.9059592266317975},2,0.16700000000000001,"gamma",143.42572340349238,1.3944500000000002E-2,null,"The frequency of use for PSA in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["ECG resource use estimate (per 3 months) ",{"$f":"IF(Ind_PSA=0,D248,C248)","v":0},{"$f":"D248","v":0},0,0,"fixed",null,null,null,"The frequency of use for ECG in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Echocardiography resource use estimate (per 3 months) ",{"$f":"IF(Ind_PSA=0,D249,C249)","v":0.02},{"$f":"GAMMAINV(RAND(),G249,H249)","v":2.1435071155373641E-2},0.02,2E-3,"gamma",100.00000000000001,1.9999999999999998E-4,null,"The frequency of use for echocardiography in the progressed disease health state for those receiving the best supportive care only, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Healthcare resource use in PD - Additional chemotherapy - for Cabazitaxel and Mitoxantrone"]
["Urologist (outpatient care) resource use estimate (per 3 months) ",{"$f":"IF(Ind_PSA=0,D251,C251)","v":0.4},{"$f":"GAMMAINV(RAND(),G251,H251)","v":0.4535614548003265},0.4,3.3000000000000002E-2,"gamma",{"$f":"(D251^2)/(E251^2)","v":146.92378328741967},2.7225000000000001E-3,null,"The frequency of use for the urologist in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK observational study)"]
["Oncology ward (inpatient care) resource use estimate (per 3 months) ",0.2,{"$f":"GAMMAINV(RAND(),G252,H252)","v":0.20948002701517351},0.2,1.7000000000000001E-2,"gamma",{"$f":"(D252^2)/(E252^2)","v":138.4083044982699},1.4450000000000001E-3,null,"The frequency of use for the oncology ward in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["General ward (inpatient care) resource use estimate (per 3 months) ",0.06,6.7323675973080727E-2,0.06,5.0000000000000001E-3,"gamma",144,4.1666666666666669E-4,null,"The frequency of use for the general ward in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Urology ward (inpatient care) resource use estimate (per 3 months) ",0,{"$f":"D254","v":0},0,0,"fixed",null,null,null,"The frequency of use for the urology ward in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["CT scan resource use estimate (per 3 months) ",0.09,8.779945453166825E-2,0.09,8.0000000000000002E-3,"gamma",126.5625,7.1111111111111115E-4,null,"The frequency of use for CT scan in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["MRI resource use estimate (per 3 months) ",0.13,0.12301259470788578,0.13,1.0999999999999999E-2,"gamma",139.66942148760333,9.3076923076923068E-4,null,"The frequency of use for MRI in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Bone scan resource use estimate (per 3 months) ",0,{"$f":"D257","v":0},0,0,"fixed",null,null,null,"The frequency of use for bone scan in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Ultrasound resource use estimate (per 3 months) ",0.05,5.208182649973523E-2,0.05,4.0000000000000001E-3,"gamma",156.25000000000003,3.1999999999999997E-4,null,"The frequency of use for the ultrasound in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Conventional x-ray resource use estimate (per 3 months) ",0.05,5.3213221117599012E-2,0.05,4.0000000000000001E-3,"gamma",156.25000000000003,3.1999999999999997E-4,null,"The frequency of use for the conventional x-ray in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Complete blood count resource use estimate (per 3 months) ",3.47,3.4478927160690089,3.47,0.28899999999999998,"gamma",144.16613785754484,2.4069452449567718E-2,null,"The frequency of use for complete blood count in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Chemistry panel resource use estimate (per 3 months) ",4.4400000000000004,4.5426944328340326,4.4400000000000004,0.37,"gamma",144.00000000000003,3.0833333333333331E-2,null,"The frequency of use for the chemistry panel in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Liver function test resource use estimate (per 3 months) ",2,1.8981536116978377,2,0.16700000000000001,"gamma",143.42572340349238,1.3944500000000002E-2,null,"The frequency of use for liver function test in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["PSA resource use estimate (per 3 months) ",2,1.9331514747395966,2,0.16700000000000001,"gamma",143.42572340349238,1.3944500000000002E-2,null,"The frequency of use for PSA in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["ECG resource use estimate (per 3 months) ",1,1.0440843800621455,1,8.3000000000000004E-2,"gamma",145.15894904920887,6.889000000000001E-3,null,"The frequency of use for ECG in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Echocardiography resource use estimate (per 3 months) ",0,{"$f":"D265","v":0},0,0,"fixed",null,null,null,"The frequency of use for echocardiography in the progressed disease health state for those receiving additional chemotherapy, per 3 months","Company submission from NICE TA391, Table 67 (from the UK treatment audit)"]
["Healthcare resource use in PD for both additional chemotherapy and best supportive care - for Cabazitaxel and Mitoxantrone"]
["Percentage used for SE calculation for the average length of stay inpatient care (days) per visit",{"$f":"IF(Ind_PSA=0,D267,C267)","v":0.1},{"$f":"D267","v":0.1},0.1,null,"fixed",null,null,null,"Assumed percentage used for SE calculation for  the average length of stay inpatient care (days) per visit","The assumption is based on information provided before about the healthcare resource use in SD"]
["Oncology ward average length of stay inpatient care (days) per visit",{"$f":"IF(Ind_PSA=0,D268,C268)","v":6.5},{"$f":"GAMMAINV(RAND(),G268,H268)","v":6.7447370875565182},6.5,{"$f":"perc_SD_avg_lengthofstay_inpatient_care*D268","v":0.65},"gamma",{"$f":"(D268^2)/(E268^2)","v":99.999999999999986},{"$f":"(E268^2)/(D268)","v":6.5000000000000002E-2},null,"The average length of stay inpatient care (days) per visit for oncology ward in the progressed disease health state","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table 11 of the instructions assignment 3 word file."]
["General ward average length of stay inpatient care (days) per visit",{"$f":"IF(Ind_PSA=0,D269,C269)","v":6.5},5.7707709196379549,6.5,{"$f":"perc_SD_avg_lengthofstay_inpatient_care*D269","v":0.65},"gamma",{"$f":"(D269^2)/(E269^2)","v":99.999999999999986},6.5000000000000002E-2,null,"The average length of stay inpatient care (days) per visit for general ward in the progressed disease health state","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table 11 of the instructions assignment 3 word file."]
["Urology ward average length of stay inpatient care (days) per visit",{"$f":"IF(Ind_PSA=0,D270,C270)","v":6.5},5.4173272080614394,6.5,{"$f":"perc_SD_avg_lengthofstay_inpatient_care*D270","v":0.65},"gamma",99.999999999999986,6.5000000000000002E-2,null,"The average length of stay inpatient care (days) per visit for urology ward in the progressed disease health state","Source for this wasn't given in the instruction assignment 3. We got the value from the text below Table 11 of the instructions assignment 3 word file."]
[]
["Best supportive care costs after progression for Cabazitaxel and Mitoxantrone"]
["Percentage used for SE calculation for the total best suportive care cost after progression",{"$f":"IF(Ind_PSA=0,D273,C273)","v":0.2},{"$f":"D273","v":0.2},0.2,null,"fixed",null,null,null,"Assumed percentage used for SE calculation for the total best suportive care cost after progression","Based on own reasoning."]
["Total costs of analgesics, steroids, palliative radiotherapy and bisphosphonate per cycle (2014/2015)",{"$f":"IF(Ind_PSA=0,D274,C274)","v":41.68},{"$f":"GAMMAINV(RAND(),G274,H274)","v":47.234848585301734},41.68,{"$f":"perc_SD_best_supportive_care_PD*D274","v":8.3360000000000003},"gamma",{"$f":"(D274^2)/(E274^2)","v":24.999999999999993},{"$f":"(E274^2)/(D274)","v":1.6672000000000002},null,"The overall cost estimate (in £) for best supportive care after progression, consisting of analgesics, steroids, palliative radiotherapy and bisphosphonate per 3 weeks ","ERG report of TA391, p115"]
[]
["End of life costs for Cabazitaxel and Mitoxantrone"]
["Percentage used for SE calculation for the end of life costs",{"$f":"IF(Ind_PSA=0,D277,C277)","v":0.2},{"$f":"D277","v":0.2},0.2,null,"fixed",null,null,null,"Assumed percentage used for SE calculation for the end of life costs","The assumption is based on information from: PSSRU, 2023"]
["End of life costs (2023)",{"$f":"IF(Ind_PSA=0,D278,C278)","v":6202},{"$f":"GAMMAINV(RAND(),G278,H278)","v":6269.5124965783198},6202,{"$f":"perc_SE_end_of_life_costs*D278","v":1240.4000000000001},"gamma",{"$f":"(D278^2)/(E278^2)","v":24.999999999999996},{"$f":"(E278^2)/(D278)","v":248.08},null,"The costs (in £) of end of life care, assuming 30 days of palliative care, average value for those above 19 years","PSSRU 2023"]

{"sheet":"Costs","index":3,"n_rows":74,"n_cols":42,"rows_kept":74,"cut":false,"hidden":false,"merged":[]}
["Cost overview",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Cost overview",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Cost overview"]
["Stable disease","All total costs are per person per cycle (except from the lump-sum; that is for all cycles included already)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Progressed disease",null,"All total costs are per person per cycle (except from the lump-sum; that is for all cycles included already)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Dead"]
[]
["Costs adverse events",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Number of patients receiving each additional line of chemotherapy for Mitoxantrone",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"End of life costs"]
[null,"Adverse event grade 3 or higher",null,"Unit costs","Unit costs","Incidence cabazitaxel","Incidence mitoxantrone","Costs cabazitaxel","Costs mitoxantrone",null,null,null,null,null,null,null,"Treatment","Proportion of patients",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Costs per patient","Costs per patient"]
[null,null,null,"Non-indexed","2023/2024",null,null,"2023/2024","2023/2024",null,null,null,null,null,null,null,"Docetaxel",{"$f":"docetaxel_n_patients_post_second_chemo/(docetaxel_n_patients_post_second_chemo+carboplatin_n_patients_post_second_chemo)","v":0.66666666666666663},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Non-indexed","2023/2024"]
[null,"Neutropenia",null,{"$f":"Unit_cost_AE_neutopenia","v":389},{"$f":"D7","v":389},{"$f":"p_AE_neutropenia_caba","v":0.81671159029649598},{"$f":"p_AE_neutropenia_mito","v":0.57951482479784366},{"$f":"E7*F7","v":317.70080862533695},{"$f":"E7*G7","v":225.43126684636118},null,null,null,null,null,null,null,"Carboplatin-based regimens",{"$f":"carboplatin_n_patients_post_second_chemo/(docetaxel_n_patients_post_second_chemo+carboplatin_n_patients_post_second_chemo)","v":0.33333333333333331},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"End_of_life_costs","v":6202},{"$f":"AO7*Inflation_index_23_24","v":6469.3061999999991}]
[null,"Febrile neutropenia",null,{"$f":"Unit_cost_AE_febrile_neutropenia","v":2545},{"$f":"D8*Inflation_index_16_17*Inflation_index_17_18*Inflation_index_18_19*Inflation_index_19_20*Inflation_index_20_21*Inflation_index_21_22*Inflation_index_22_23*Inflation_index_23_24","v":3212.6505289021547},{"$f":"p_AE_febrile_neutropenia_caba","v":7.5471698113207544E-2},{"$f":"p_AE_febrile_neutropenia_mito","v":1.3477088948787063E-2},{"$f":"E8*F8","v":242.46419086053996},{"$f":"E8*G8","v":43.29717693938214}]
[null,"Leukopenia",null,{"$f":"Unit_cost_AE_leukopenia","v":389},{"$f":"D9","v":389},{"$f":"p_AE_leukopenia_caba","v":0.68194070080862534},{"$f":"p_AE_leukopenia_mito","v":0.42318059299191374},265.27493261455527,164.61725067385444,null,null,null,null,null,null,null,"Number of patients receiving each additional line of chemotherapy for Cabazitaxel"]
[null,"Anaemia",null,{"$f":"unit_cost_AE_anaemia","v":393},393,{"$f":"p_AE_anaemia_caba","v":0.10512129380053908},{"$f":"p_AE_anaemia_mito","v":4.8517520215633422E-2},41.312668463611857,19.067385444743934,null,null,null,null,null,null,null,"Treatment","Proportion of patients"]
[null,"Diarrhoea",null,{"$f":"unit_cost_AE_diarrhoea","v":511},511,{"$f":"p_AE_diarrhoea_caba","v":6.1994609164420483E-2},{"$f":"p_AE_diarrhoea_mito","v":2.6954177897574125E-3},31.679245283018869,1.3773584905660379,null,null,null,null,null,null,null,"Docetaxel",{"$f":"docetaxel_n_patients_post_second_chemo/(docetaxel_n_patients_post_second_chemo+carboplatin_n_patients_post_second_chemo+mito_n_patients_post_second_chemo)","v":0.54545454545454541}]
[null,"Fatigue",null,{"$f":"unit_cost_AE_fatigue","v":520},520,{"$f":"p_AE_fatigue_caba","v":4.8517520215633422E-2},{"$f":"p_AE_fatigue_mito","v":2.9649595687331536E-2},25.229110512129381,15.417789757412399,null,null,null,null,null,null,null,"Carboplatin-based regimens",{"$f":"carboplatin_n_patients_post_second_chemo/(docetaxel_n_patients_post_second_chemo+carboplatin_n_patients_post_second_chemo+mito_n_patients_post_second_chemo)","v":0.27272727272727271}]
[null,"Asthenia",null,{"$f":"unit_cost_AE_asthenia","v":520},{"$f":"D13","v":520},{"$f":"p_AE_asthenia_caba","v":4.5822102425876012E-2},{"$f":"p_AE_asthenia_mito","v":2.4258760107816711E-2},23.827493261455526,12.614555256064691,null,null,null,null,null,null,null,"Mitoxantrone",{"$f":"mito_n_patients_post_second_chemo/(docetaxel_n_patients_post_second_chemo+carboplatin_n_patients_post_second_chemo+mito_n_patients_post_second_chemo)","v":0.18181818181818182}]
[null,null,null,null,null,null,null,{"$f":"SUM(H7:H13)","v":947.48844962064788},{"$f":"SUM(I7:I13)","v":481.82278340838485},"Total costs adverse events for Cabazitaxel and Mitoxantrone"]
["Drug acquisition costs in SD",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Post-second-line chemotherapy mix lump-sum cost for Mitoxantrone"]
[null,"Vial acquisition costs (in £)","Body surface area (m2)","Dosage (mg) per m2","Dosage per cycle (mg)","Dosage (mg)  per vial","Number of vials needed per cycle","Drug acquisition cost per cycle",null,null,null,null,null,null,null,null,"Treatment","Cost (in £) per mg","Body surface area (m2)","Dosage (mg) per m2","Dosing per cycle","Dosage (mg) per cycle","Costs per cycle (in £)","Max number of cycles","Total lump sum costs adjusted for proportion of patients receiving each additional line of chemo","Proportion of patients from total, receiving post-second-line chemotherapy mix","Total lump sum costs adjusted for share of patients recieving post-second line chemotherapy mix",null,"Premedication cost per cycle","Premedication cost adjusted for proportion of patients per cycle","Premedication cost adjusted for proportion of patients receiving each additional line of chemo and maximum cycle length","Total lump sum for premedication costs adjusted for share of patients receiving post-second line chemotherapy mix",null,"Administration cost per cycle","Administration cost adjusted for proportion of patients per cycle","Administration cost adjusted for proportion of patients and maximum cycle length","Total lump sum for administration cost adjusted for share of patients receiving post-second line chemotheraphy mix"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Docetaxel",{"$f":"cost_post_second_line_chemo_docetaxel_permg","v":0.63},{"$f":"body_surface_area","v":2.0099999999999998},{"$f":"post_second_line_dosage_docetaxel_perm2","v":75},{"$f":"post_second_line_chemo_dosing_docetaxel_percycle","v":1},{"$f":"S17*T17*U17","v":150.74999999999997},{"$f":"V17*R17","v":94.972499999999982},{"$f":"n_cycles_docetaxel_max","v":10},{"$f":"W17*X17*R6","v":633.14999999999986},{"$f":"proportion_patients_further_chemo","v":0.5592841163310962},{"$f":"Y17*Z17","v":354.11073825503348},null,{"$f":"SD_pre_medication_costs_mito_per_cycle","v":32.766058494802962},{"$f":"AC17*R6","v":21.844038996535307},{"$f":"AD17*X17","v":218.44038996535306},{"$f":"AE17*Z17","v":122.17024047279254},null,{"$f":"SD_total_administration_cost_mito","v":480},{"$f":"AH17*R6","v":320},{"$f":"AI17*X17","v":3200},{"$f":"AJ17*Z17","v":1789.7091722595078}]
["Cabazitaxel ",{"$f":"Vial_acq_costs_Caba","v":151.07},{"$f":"body_surface_area","v":2.0099999999999998},{"$f":"dosage_per_m2_Caba","v":25},{"$f":"C18*D18","v":50.249999999999993},{"$f":"dosage_per_vial_Caba","v":60},{"$f":"CEILING(E18/F18,1)","v":1},{"$f":"G18*B18","v":151.07},"Total drug acquisition costs Cabazitaxel",null,null,null,null,null,null,null,"Carboplatin-based regimens",{"$f":"cost_post_second_line_chemo_carboplatin_permg","v":0.39},{"$f":"body_surface_area","v":2.0099999999999998},{"$f":"post_second_line_dosage_carboplatin_perm2","v":360},{"$f":"post_second_line_chemo_dosing_carboplatin_percycle","v":1},{"$f":"S18*T18*U18","v":723.59999999999991},{"$f":"V18*R18","v":282.20399999999995},{"$f":"n_cycles_carboplatin_max","v":6},{"$f":"W18*X18*R7","v":564.4079999999999},{"$f":"proportion_patients_further_chemo","v":0.5592841163310962},{"$f":"Y18*Z18","v":315.66442953020129},null,{"$f":"SD_pre_medication_costs_mito_per_cycle","v":32.766058494802962},{"$f":"AC18*R7","v":10.922019498267654},{"$f":"AD18*X18","v":65.532116989605925},{"$f":"AE18*Z18","v":36.651072141837766},null,{"$f":"SD_total_administration_cost_mito","v":480},{"$f":"AH18*R7","v":160},{"$f":"AI18*X18","v":960},{"$f":"AJ18*Z18","v":536.91275167785238}]
["Mitoxantrone",{"$f":"Vial_acq_costs_Mito","v":94.72},{"$f":"body_surface_area","v":2.0099999999999998},{"$f":"dosage_per_m2_mito","v":12},{"$f":"C19*D19","v":24.119999999999997},{"$f":"dosage_per_vial_Mito","v":20},{"$f":"CEILING(E19/F19,1)","v":2},{"$f":"G19*B19","v":189.44},"Total drug acquisition costs Mitoxantrone",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AA17:AA18)","v":669.77516778523477},"Total lump sum of drug acquisition costs for Mitoxantrone ",null,null,null,{"$f":"SUM(AF17,AF18)","v":158.8213126146303},"Total lumpsum of premedication costs for Mitoxantrone ",null,null,null,{"$f":"SUM(AK17:AK18)","v":2326.6219239373604},"Total lumpsum of administration costs for Mitoxantrone "]
["Premedication costs",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Post-second-line chemotherapy mix lump-sum cost for Cabazitaxel"]
["Premedication","Prevalence Cabazitaxel","Prevalence Mitoxantrone","Costs per pack  (in £)","Pack size","Costs per tablet  (in £)","Dosage (mg)","Unit cost per mg (in £) for 2023/2024","Dosing per cycle","Cycle cost (in £)","Costs for Mitoxantrone per cycle","Costs for Cabazitaxel per cycle",null,null,null,null,"Treatment","Cost (in £) per mg","Body surface area (m2)","Dosage (mg) per m2","Dosing per cycle","Dosage (mg) per cycle ","Costs per cycle (in £)","Max number of cycles","Total lump sum costs adjusted for proportion of patients receiving each additional line of chemo","Proportion of patients from total, receiving post-second-line chemotherapy mix","Total lump sum costs adjusted for share of patients recieving post-second line chemotherapy mix",null,"Premedication cost per cycle","Premedication cost adjusted for proportion of patients per cycle","Premedication cost adjusted for proportion of patients receiving each additional line of chemo and maximum cycle length","Total lump sum for premedication costs adjusted for share of patients receiving post-second line chemotherapy mix",null,"Administration cost per cycle","Administration cost adjusted for proportion of patients per cycle","Administration cost adjusted for proportion of patients and maximum cycle length","Total lump sum for administration cost adjusted for share of patients receiving post-second line chemotheraphy mix"]
["Antihistamine",{"$f":"Antihistamine_prevalence_Caba","v":1},{"$f":"Antihistamine_prevalence_Mito","v":0.09},{"$f":"Antihistamine_cost_pack","v":0.38},{"$f":"Antihistamine_pack_size","v":28},{"$f":"D22/E22","v":1.3571428571428571E-2},"-","-",{"$f":"Antihistamine_dosing_cycle","v":1},{"$f":"I22*F22","v":1.3571428571428571E-2},{"$f":"J22*C22","v":1.2214285714285714E-3},{"$f":"J22*B22","v":1.3571428571428571E-2},null,null,null,null,"Docetaxel",{"$f":"cost_post_second_line_chemo_docetaxel_permg","v":0.63},{"$f":"body_surface_area","v":2.0099999999999998},{"$f":"post_second_line_dosage_docetaxel_perm2","v":75},{"$f":"post_second_line_chemo_dosing_docetaxel_percycle","v":1},{"$f":"S22*T22*U22","v":150.74999999999997},{"$f":"R22*V22","v":94.972499999999982},{"$f":"n_cycles_docetaxel_max","v":10},{"$f":"W22*X22*R11","v":518.03181818181804},{"$f":"proportion_patients_further_chemo","v":0.5592841163310962},{"$f":"Y22*Z22","v":289.72696766320922},null,{"$f":"SD_pre_medication_costs_mito_per_cycle","v":32.766058494802962},{"$f":"AC22*R11","v":17.872395542619795},{"$f":"AD22*X22","v":178.72395542619796},{"$f":"AE22*Z22","v":99.957469477739352},null,{"$f":"SD_total_administration_cost_mito","v":480},{"$f":"AH22*R11","v":261.81818181818181},{"$f":"AI22*X22","v":2618.181818181818},{"$f":"AJ22*Z22","v":1464.3075045759608}]
["H2 antagonist",{"$f":"H2_antagonist_prevalence_Caba","v":1},{"$f":"H2_antagonist_prevalence_Mito","v":0.25},{"$f":"H2_antagonist_costs_pack","v":5.41},{"$f":"H2_antagonist_pack_size","v":60},{"$f":"D23/E23","v":9.0166666666666673E-2},"-","-",{"$f":"H2_antagonist_dosing_cycle","v":1},{"$f":"I23*F23","v":9.0166666666666673E-2},{"$f":"J23*C23","v":2.2541666666666668E-2},{"$f":"J23*B23","v":9.0166666666666673E-2},null,null,null,null,"Carboplatin-based regimens",{"$f":"cost_post_second_line_chemo_carboplatin_permg","v":0.39},{"$f":"body_surface_area","v":2.0099999999999998},{"$f":"post_second_line_dosage_carboplatin_perm2","v":360},{"$f":"post_second_line_chemo_dosing_carboplatin_percycle","v":1},{"$f":"S23*T23*U23","v":723.59999999999991},{"$f":"V23*R23","v":282.20399999999995},{"$f":"n_cycles_carboplatin_max","v":6},{"$f":"W23*X23*R12","v":461.7883636363635},{"$f":"proportion_patients_further_chemo","v":0.5592841163310962},{"$f":"Z23*Y23","v":258.2708968883465},null,{"$f":"SD_pre_medication_costs_mito_per_cycle","v":32.766058494802962},{"$f":"AC23*R12","v":8.9361977713098977},{"$f":"AD23*X23","v":53.617186627859382},{"$f":"AE23*Z23","v":29.987240843321803},null,{"$f":"SD_total_administration_cost_mito","v":480},{"$f":"AH23*R12","v":130.90909090909091},{"$f":"AI23*X23","v":785.4545454545455},{"$f":"AJ23*Z23","v":439.29225137278831}]
["Anti-emetics",{"$f":"Anti_emetics_prevalence_Caba","v":1},{"$f":"Anti_emetics_prevalence_Mito","v":1},{"$f":"Anti_emetics_costs_pack","v":3.5},{"$f":"Anti_emetics_pack_size","v":10},{"$f":"D24/E24","v":0.35},"-","-",{"$f":"Anti_emetics_dosing_cycle","v":1},{"$f":"I24*F24","v":0.35},{"$f":"J24*C24","v":0.35},{"$f":"J24*B24","v":0.35},null,null,null,null,"Mitoxantrone","-","-","-","-","- ",{"$f":"SD_costs_drug_acquisition_per_cycle_mito","v":189.44},{"$f":"n_cycles_mitoxantrone_max","v":10},{"$f":"W24*X24*R13","v":344.43636363636364},{"$f":"proportion_patients_further_chemo","v":0.5592841163310962},{"$f":"Z24*Y24","v":192.63778726865976},null,{"$f":"SD_pre_medication_costs_mito_per_cycle","v":32.766058494802962},{"$f":"AC24*R13","v":5.9574651808732657},{"$f":"AD24*X24","v":59.574651808732654},{"$f":"AE24*Z24","v":33.319156492579786},null,{"$f":"SD_total_administration_cost_mito","v":480},{"$f":"AH24*R13","v":87.27272727272728},{"$f":"AI24*X24","v":872.72727272727275},{"$f":"AJ24*Z24","v":488.10250152532035}]
["Corticosteroids",{"$f":"Corticosteroids_prevalence_Caba","v":1},{"$f":"Corticosteroids_prevalence_Mito","v":0.56000000000000005},{"$f":"Corticosteroids_costs_pack","v":39.6},{"$f":"Corticosteroids_pack_size","v":50},{"$f":"D25/E25","v":0.79200000000000004},"-","-",{"$f":"Corticosteroids_dosing_cycle","v":1},{"$f":"I25*F25","v":0.79200000000000004},{"$f":"J25*C25","v":0.44352000000000008},{"$f":"J25*B25","v":0.79200000000000004},null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AA22:AA24)","v":740.63565182021546},"Total lump sum of drug acquisition costs for Cabazitaxel",null,null,null,{"$f":"SUM(AF22:AF24)","v":163.26386681364096},"Total lumpsum of premedication costs for Cabazitaxel",null,null,null,{"$f":"SUM(AK22:AK24)","v":2391.7022574740695},"Total lumpsum of administration costs for Cabazitaxel "]
["Prophylaxis",{"$f":"Prophylaxis_prevalence_Caba","v":0.25},{"$f":"Prophylaxis_prevalence_Mito","v":0.1},"-","-","-",{"$f":"Prohaphylaxis_dosage*avg_body_weight","v":0.35000000000000003},{"$f":"Prophylaxis_unit_costs*Inflation_index_21_22*Inflation_index_22_23*Inflation_index_23_24","v":222.63954982275166},{"$f":"Prophylaxis_dosing_cycle","v":4.0999999999999996},{"$f":"G26*I26*H26","v":319.48775399564863},{"$f":"J26*C26","v":31.948775399564866},{"$f":"J26*B26","v":79.871938498912158},null,null,null,null,"Concomitant medication costs "]
[null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(K22:K26)","v":32.766058494802962},{"$f":"SUM(L22:L26)","v":81.117676594150254},"Total pre-medication costs for Cabazitaxel and Mitoxantrone",null,null,null,"Concomitant medication ","Costs per pack  (in £)","Pack size","Costs per tablet  (in £)","Dosage(tablet) per day","Dosage (tablet) per cycle","Cycle cost (in £)","Concomitant medication cost per cycle"]
["Concomitant medication costs",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Prednisolone",{"$f":"prednisolone_costs_per_pack","v":0.31},{"$f":"prednisolone_pack_size","v":28},{"$f":"R28/S28","v":1.1071428571428571E-2},{"$f":"prednisolone_dosage_per_day","v":2},{"$f":"U28*cycle_length_days","v":42},{"$f":"T28*V28","v":0.46499999999999997},{"$f":"W28","v":0.46499999999999997}]
["Concomitant medication ","Costs per pack  (in £)","Pack size","Costs per tablet  (in £)","Dosage(tablet) per day","Dosage (tablet) per cycle","Cycle cost (in £)","Concomitant medication cost per cycle",null,null,null,null,null,null,null,null,"LHRH (leuroproreling/goserelin)","-","-","-","-","-",{"$f":"LHRH_cycle_cost","v":77.31},{"$f":"W29","v":77.31}]
["Prednisolone",{"$f":"prednisolone_costs_per_pack","v":0.31},{"$f":"prednisolone_pack_size","v":28},{"$f":"B30/C30","v":1.1071428571428571E-2},{"$f":"prednisolone_dosage_per_day","v":2},{"$f":"E30*cycle_length_days","v":42},{"$f":"F30*D30","v":0.46499999999999997},{"$f":"G30","v":0.46499999999999997},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(X28:X29)","v":77.775000000000006},"Total concomitant medication cost for mitoxantrone and cabazitaxel per cycle"]
["LHRH (leuroprorelin/goserelin)","-","-","-",null,"-",{"$f":"LHRH_cycle_cost","v":77.31},{"$f":"G31","v":77.31}]
[null,null,null,null,null,null,null,{"$f":"SUM(H30:H31)","v":77.775000000000006},"Total concomitation medication cost for Mitoxantrone and Cabazitaxel per cycle",null,null,null,null,null,null,null,"Health care resource use costs best supportive care only"]
["Chemotherapy administration cost",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Health care resource use  ","Health care resource use estimates (per 3 months)","Health care resource use estimates (per cycle)","Average length of stay inpatient care (days) per visit","Health care resource use unit cost (in £)","Health care resource use cost (in £) per cycle","Total health care resource use cost (in £) per cycle"]
[null,"Costs (in £) outpatient visit chemotherapy per cycle","Hourly cost (in £) pharmacist","Preparation time pharmacist (min) per administration","Preparation time pharmacist (hour) per administration","Costs (in £) pharmacist per cycle","Total chemotherapy administration costs per cycle",null,null,null,null,null,null,null,null,null,"Urologist (outpatient care)",{"$f":"Usage_PD_supportive_care_urologist_per_3_months","v":0.05},{"$f":"(R34/n_weeks_3_months)*cycle_length_weeks","v":1.1538461538461539E-2},"-",{"$f":"unit_cost_urologist","v":163},{"$f":"S34*U34","v":1.880769230769231},{"$f":"SUM(V34:V48)","v":348.18692307692305},"for Mitoxantrone and Cabazitaxel"]
["Cabazitaxel ",{"$f":"Cost_infusion_chemotherapy_per_cycle","v":430},{"$f":"costs_hourly_pharmacist","v":50},{"$f":"Prep_time_admin_caba","v":15},{"$f":"calculation_minutes_to_hours*Prep_time_admin_caba","v":0.25},{"$f":"costs_hourly_pharmacist*E35","v":12.5},{"$f":"B35+F35","v":442.5},"Total chemotherapy medication cost for Cabazitaxel per cycle",null,null,null,null,null,null,null,null,"Oncology ward (inpatient care)",{"$f":"Usage_PD_supportive_care_oncology_ward_per_3_months","v":0.13},{"$f":"(R35/n_weeks_3_months)*cycle_length_weeks","v":0.03},{"$f":"PD_oncology_ward_length_stay_per_visit","v":6.5},{"$f":"unit_cost_oncology_ward","v":824},{"$f":"S35*T35*U35","v":160.68}]
["Mitoxantrone",{"$f":"Cost_infusion_chemotherapy_per_cycle","v":430},{"$f":"costs_hourly_pharmacist","v":50},{"$f":"prep_time_admin_mito","v":60},{"$f":"calculation_minutes_to_hours*prep_time_admin_mito","v":1},{"$f":"costs_hourly_pharmacist*E36","v":50},{"$f":"F36+B36","v":480},"Total chemotherapy medication cost for Mitoxantrone per cycle",null,null,null,null,null,null,null,null,"General ward (inpatient care)",{"$f":"Usage_PD_supportive_care_general_ward_per_3_months","v":0.09},{"$f":"(R36/n_weeks_3_months)*cycle_length_weeks","v":2.0769230769230769E-2},{"$f":"PD_general_ward_length_stay_per_visit","v":6.5},{"$f":"unit_cost_general_ward","v":824},{"$f":"S36*T36*U36","v":111.24000000000001}]
["Health care resource use cost",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Urology ward (inpatient care)",{"$f":"Usage_PD_supportive_care_urology_ward_per_3_months","v":0.02},{"$f":"(R37/n_weeks_3_months)*cycle_length_weeks","v":4.6153846153846149E-3},{"$f":"PD_urology_ward_length_stay_per_visit","v":6.5},{"$f":"unit_cost_urology_ward","v":824},{"$f":"S37*T37*U37","v":24.72}]
["Health care resource use  ","Health care resource use estimates (per 3 months)","Health care resource use estimates (per cycle)","Average length of stay inpatient care (days) per visit","Health care resource use unit cost (in £)","Health care resource use cost (in £) per cycle","Total health care resource use cost (in £) per cycle",null,null,null,null,null,null,null,null,null,"CT scan",{"$f":"Usage_PD_supportive_care_ct_per_3_months","v":0.47},{"$f":"(R38/n_weeks_3_months)*cycle_length_weeks","v":0.10846153846153847},"-",{"$f":"unit_cost_CT_scan","v":142},{"$f":"S38*U38","v":15.401538461538463}]
["Clinical oncologist",{"$f":"Usage_SD_clinical_oncologist_per_3_months","v":4.3},{"$f":"(B39/n_weeks_3_months)*cycle_length_weeks","v":0.99230769230769234},"-",{"$f":"unit_cost_clinical_oncologist","v":193},{"$f":"E39*C39","v":191.51538461538462},{"$f":"SUM(F39:F53)","v":355.11359999999991},"Total health care resource use costs for Mitoxantrone and Cabazitaxel per cycle",null,null,null,null,null,null,null,null,"MRI",{"$f":"Usage_PD_supportive_care_MRI_per_3_months","v":0.15},{"$f":"(R39/n_weeks_3_months)*cycle_length_weeks","v":3.461538461538461E-2},"-",{"$f":"unit_cost_MRI_scan","v":232},8.0307692307692289]
["Urologist (outpatient care)",{"$f":"Usage_SD_urologist_per_3_months","v":7.0000000000000007E-2},{"$f":"(B40/n_weeks_3_months)*cycle_length_weeks","v":1.6153846153846158E-2},"-",{"$f":"unit_cost_urologist","v":163},{"$f":"E40*C40","v":2.6330769230769238},null,null,null,null,null,null,null,null,null,null,"Bone scan",{"$f":"Usage_PD_supportive_care_bonescan_per_3_months","v":0.14000000000000001},{"$f":"(R40/n_weeks_3_months)*cycle_length_weeks","v":3.2307692307692315E-2},"-",{"$f":"unit_cost_bone_scan","v":271},8.7553846153846173]
["Oncology ward (inpatient care)",{"$f":"Usage_SD_oncology_ward_per_3_months","v":0.03},{"$f":"(B41/n_weeks_3_months)*cycle_length_weeks","v":6.9230769230769224E-3},{"$f":"SD_oncology_ward_length_stay_per_visit","v":8.17},{"$f":"unit_cost_oncology_ward","v":824},{"$f":"E41*C41*D41","v":46.606707692307687},null,null,null,null,null,null,null,null,null,null,"Ultrasound",{"$f":"Usage_PD_supportive_care_ultrasound_per_3_months","v":0},{"$f":"(R41/n_weeks_3_months)*cycle_length_weeks","v":0},"-",{"$f":"unit_cost_ultrasound","v":71},0]
["General ward (inpatient care)",{"$f":"Usage_SD_general_ward_per_3_months","v":0.04},{"$f":"(B42/n_weeks_3_months)*cycle_length_weeks","v":9.2307692307692299E-3},{"$f":"SD_general_ward_length_stay_per_visit","v":8.17},{"$f":"unit_cost_general_ward","v":824},{"$f":"E42*C42*D42","v":62.142276923076921},null,null,null,null,null,null,null,null,null,null,"Conventional x-ray",{"$f":"Usage_PD_supportive_care_xray_per_3_months","v":0.84},{"$f":"(R42/n_weeks_3_months)*cycle_length_weeks","v":0.19384615384615383},"-",{"$f":"unit_cost_conventional_xray","v":42},8.1415384615384614]
["CT scan",{"$f":"Usage_SD_CT_per_3_months","v":0.15},{"$f":"(B43/n_weeks_3_months)*cycle_length_weeks","v":3.461538461538461E-2},"-",{"$f":"unit_cost_CT_scan","v":142},{"$f":"E43*C43","v":4.9153846153846148},null,null,null,null,null,null,null,null,null,null,"Complete blood count",{"$f":"Usage_PD_supportive_care_bloodcount_per_3_months","v":4.12},{"$f":"(R43/n_weeks_3_months)*cycle_length_weeks","v":0.95076923076923081},"-",{"$f":"unit_cost_complete_blood_count","v":3},2.8523076923076927]
["MRI",{"$f":"Usage_SD_MRI_per_3_months","v":0.04},{"$f":"(B44/n_weeks_3_months)*cycle_length_weeks","v":9.2307692307692299E-3},"-",{"$f":"unit_cost_MRI_scan","v":232},2.1415384615384614,null,null,null,null,null,null,null,null,null,null,"Chemistry panel",{"$f":"Usage_PD_supportive_care_chemistry_panel_per_3_months","v":3.89},{"$f":"(R44/n_weeks_3_months)*cycle_length_weeks","v":0.89769230769230779},"-",{"$f":"unit_cost_chemistry_panel","v":2},1.7953846153846156]
["Bone scan",{"$f":"Usage_SD_bone_scan_per_3_months","v":0.09},{"$f":"(B45/n_weeks_3_months)*cycle_length_weeks","v":2.0769230769230769E-2},"-",{"$f":"unit_cost_bone_scan","v":271},5.6284615384615382,null,null,null,null,null,null,null,null,null,null,"Liver function test",{"$f":"Usage_PD_supportive_care_liver_function_test_per_3_months","v":2},{"$f":"(R45/n_weeks_3_months)*cycle_length_weeks","v":0.46153846153846156},"-",{"$f":"unit_cost_liver_function_test","v":7},3.2307692307692308]
["Ultrasound",{"$f":"Usage_SD_ultrasound_per_3_months","v":0.04},{"$f":"(B46/n_weeks_3_months)*cycle_length_weeks","v":9.2307692307692299E-3},"-",{"$f":"unit_cost_ultrasound","v":71},0.65538461538461534,null,null,null,null,null,null,null,null,null,null,"PSA ",{"$f":"Usage_PD_supportive_care_PSA_per_3_months","v":2},{"$f":"(R46/n_weeks_3_months)*cycle_length_weeks","v":0.46153846153846156},"-",{"$f":"unit_cost_psa","v":2},0.92307692307692313]
["Conventional x-ray",{"$f":"Usage_SD_xray_per_3_months","v":0.13},{"$f":"(B47/n_weeks_3_months)*cycle_length_weeks","v":0.03},"-",{"$f":"unit_cost_conventional_xray","v":42},1.26,null,null,null,null,null,null,null,null,null,null,"ECG",{"$f":"Usage_PD_supportive_care_ECG_per_3_months","v":0},{"$f":"(R47/n_weeks_3_months)*cycle_length_weeks","v":0},"-",{"$f":"unit_cost_ECG","v":118},0]
["Complete blood count",{"$f":"Usage_SD_blood_count_per_3_months","v":4.96},{"$f":"(B48/n_weeks_3_months)*cycle_length_weeks","v":1.1446153846153846},"-",{"$f":"unit_cost_complete_blood_count","v":3},3.4338461538461535,null,null,null,null,null,null,null,null,null,null,"Echocardiography",{"$f":"Usage_PD_supportive_care_echocardiography_per_3_months","v":0.02},{"$f":"(R48/n_weeks_3_months)*cycle_length_weeks","v":4.6153846153846149E-3},"-",{"$f":"unit_cost_echocardiography","v":116},0.53538461538461535]
["Chemistry panel",{"$f":"Usage_SD_chemistry_panel_per_3_months","v":6.06},{"$f":"(B49/n_weeks_3_months)*cycle_length_weeks","v":1.3984615384615384},"-",{"$f":"unit_cost_chemistry_panel","v":2},2.7969230769230768,null,null,null,null,null,null,null,null,null,null,"Health care resource use costs additional chemotherapy"]
["Liver function test",{"$f":"Usage_SD_liver_function_test_per_3_months","v":2},{"$f":"(B50/n_weeks_3_months)*cycle_length_weeks","v":0.46153846153846156},"-",{"$f":"unit_cost_liver_function_test","v":7},3.2307692307692308,null,null,null,null,null,null,null,null,null,null,"Health care resource use  ","Health care resource use estimates (per 3 months)","Health care resource use estimates (per cycle)","Average length of stay inpatient care (days) per visit","Health care resource use unit cost (in £)","Health care resource use cost (in £) per cycle","Total health care resource use cost (in £) per cycle"]
["PSA ",{"$f":"Usage_SD_PSA_per_3_months","v":2},{"$f":"(B51/n_weeks_3_months)*cycle_length_weeks","v":0.46153846153846156},"-",{"$f":"unit_cost_psa","v":2},0.92307692307692313,null,null,null,null,null,null,null,null,null,null,"Urologist (outpatient care)",{"$f":"Usage_PD_additional_chemo_urologist_per_3_months","v":0.4},{"$f":"(R51/n_weeks_3_months)*cycle_length_weeks","v":9.2307692307692313E-2},"-",{"$f":"unit_cost_urologist","v":163},{"$f":"U51*S51","v":15.046153846153848},{"$f":"SUM(V51:V65)","v":383.45538461538462},"for Mitoxantrone and Cabazitaxel"]
["ECG",{"$f":"Usage_SD_ECG_per_3_months","v":1},{"$f":"(B52/n_weeks_3_months)*cycle_length_weeks","v":0.23076923076923078},"-",{"$f":"unit_cost_ECG","v":118},27.230769230769234,null,null,null,null,null,null,null,null,null,null,"Oncology ward (inpatient care)",{"$f":"Usage_PD_additional_chemo_oncology_ward_per_3_months","v":0.2},{"$f":"(R52/n_weeks_3_months)*cycle_length_weeks","v":4.6153846153846156E-2},{"$f":"PD_oncology_ward_length_stay_per_visit","v":6.5},{"$f":"unit_cost_oncology_ward","v":824},{"$f":"S52*T52*U52","v":247.20000000000005}]
["Echocardiography",{"$f":"Usage_SD_echocardiography_per_3_months","v":0},{"$f":"(B53/n_weeks_3_months)*cycle_length_weeks","v":0},"-",{"$f":"unit_cost_echocardiography","v":116},0,null,null,null,null,null,null,null,null,null,null,"General ward (inpatient care)",{"$f":"Usage_PD_additional_chemo_general_ward_per_3_months","v":0.06},{"$f":"(R53/n_weeks_3_months)*cycle_length_weeks","v":1.3846153846153845E-2},{"$f":"PD_oncology_ward_length_stay_per_visit","v":6.5},{"$f":"unit_cost_general_ward","v":824},{"$f":"S53*T53*U53","v":74.16}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Urology ward (inpatient care)",{"$f":"Usage_PD_additional_chemo_urology_ward_per_3_months","v":0},{"$f":"(R54/n_weeks_3_months)*cycle_length_weeks","v":0},{"$f":"PD_oncology_ward_length_stay_per_visit","v":6.5},{"$f":"unit_cost_urology_ward","v":824},{"$f":"S54*T54*U54","v":0}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"CT scan",{"$f":"Usage_PD_additional_chemo_ct_per_3_months","v":0.09},{"$f":"(R55/n_weeks_3_months)*cycle_length_weeks","v":2.0769230769230769E-2},"-",{"$f":"unit_cost_CT_scan","v":142},{"$f":"U55*S55","v":2.9492307692307693}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"MRI",{"$f":"Usage_PD_additional_chemo_MRI_per_3_months","v":0.13},{"$f":"(R56/n_weeks_3_months)*cycle_length_weeks","v":0.03},"-",{"$f":"unit_cost_MRI_scan","v":232},6.96]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Bone scan",{"$f":"Usage_PD_additional_chemo_bonescan_per_3_months","v":0},{"$f":"(R57/n_weeks_3_months)*cycle_length_weeks","v":0},"-",{"$f":"unit_cost_bone_scan","v":271},0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Ultrasound",{"$f":"Usage_PD_additional_chemo_ultrasound_per_3_months","v":0.05},{"$f":"(R58/n_weeks_3_months)*cycle_length_weeks","v":1.1538461538461539E-2},"-",{"$f":"unit_cost_ultrasound","v":71},0.81923076923076932]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Conventional x-ray",{"$f":"Usage_PD_additional_chemo_xray_per_3_months","v":0.05},{"$f":"(R59/n_weeks_3_months)*cycle_length_weeks","v":1.1538461538461539E-2},"-",{"$f":"unit_cost_conventional_xray","v":42},0.48461538461538467]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Complete blood count",{"$f":"Usage_PD_additional_chemo_bloodcount_per_3_months","v":3.47},{"$f":"(R60/n_weeks_3_months)*cycle_length_weeks","v":0.80076923076923079},"-",{"$f":"unit_cost_complete_blood_count","v":3},2.4023076923076925]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Chemistry panel",{"$f":"Usage_PD_additional_chemo_chemistry_panel_per_3_months","v":4.4400000000000004},{"$f":"(R61/n_weeks_3_months)*cycle_length_weeks","v":1.0246153846153847},"-",{"$f":"unit_cost_chemistry_panel","v":2},2.0492307692307694]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Liver function test",{"$f":"Usage_PD_additional_chemo_liver_function_test_per_3_months","v":2},{"$f":"(R62/n_weeks_3_months)*cycle_length_weeks","v":0.46153846153846156},"-",{"$f":"unit_cost_liver_function_test","v":7},3.2307692307692308]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PSA ",{"$f":"Usage_PD_additional_chemo_PSA_per_3_months","v":2},{"$f":"(R63/n_weeks_3_months)*cycle_length_weeks","v":0.46153846153846156},"-",{"$f":"unit_cost_psa","v":2},0.92307692307692313]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"ECG",{"$f":"Usage_PD_additional_chemo_ECG_per_3_months","v":1},{"$f":"(R64/n_weeks_3_months)*cycle_length_weeks","v":0.23076923076923078},"-",{"$f":"unit_cost_ECG","v":118},27.230769230769234]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Echocardiography",{"$f":"Usage_PD_additional_chemo_echocardiography_per_3_months","v":0},{"$f":"(R65/n_weeks_3_months)*cycle_length_weeks","v":0},"-",{"$f":"unit_cost_echocardiography","v":116},0]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Health care resource adjusted for proportion of patients"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Total healthcare resource use costs (in £) per cycle for best supportive care only","Total healthcare resource use costs (in £) per cycle for additional chemotherapy","Proportion of patients from total, receiving only best supportive care","Proportion of patients from total, receiving additional chemotherapy","Total healthcare resource use costs (in £) per cycle for best supportive care only","Total healthcare resource use costs (in £) per cycle for additional chemotherapy","Overall total Healthcare resource use costs (in £) per cycle "]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Not-corrected for proportion of patients receiving best supportive care only","Not-corrected for proportion of patients receiving additional chemo",null,null,"Corrected for proportion of patients receiving best supportive care","Corrected for proportion of patients receiving additional chemo","Corrected for proportion of patients receiving either best supportive care or additional chemo"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"W34","v":348.18692307692305},{"$f":"W51","v":383.45538461538462},{"$f":"1-proportion_patients_further_chemo","v":0.4407158836689038},{"$f":"proportion_patients_further_chemo","v":0.5592841163310962},{"$f":"Q69*S69","v":153.45150748580278},{"$f":"R69*T69","v":214.46050593701599},{"$f":"SUM(U69:V69)","v":367.91201342281875},"for Mitoxantrone and Cabazitaxel"]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Best supportive care costs"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Overall costs per cycle","Total overall costs per cycle"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Non-indexed","2023/2024"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Best supportive care ",{"$f":"Best_supportive_care_costs_PD","v":41.68},{"$f":"R74*Inflation_index_15_16*Inflation_index_16_17*Inflation_index_17_18*Inflation_index_18_19*Inflation_index_19_20*Inflation_index_20_21*Inflation_index_21_22*Inflation_index_22_23*Inflation_index_23_24","v":52.824710074978533},"for Mitoxantrone and Cabazitaxel"]

{"sheet":"Utilities","index":4,"n_rows":28,"n_cols":8,"rows_kept":28,"cut":false,"hidden":false,"merged":[[5,0,11,0],[16,0,22,0]]}
[]
[null,"Disutilities adverse events "]
[null,null,"IMPORTANT: Make sure the values in column C come from the Parameter sheet and that those cells have a name"]
[null,"Adverse event ","Incidence cabazitaxel (%)","Disutility","Duration (days)","Duration (years)","Total disutility by incidence","Total QALY lost"]
[null,null,"%(n/N)"]
["Cabazitaxel","Neutropenia",{"$f":"p_AE_neutropenia_caba","v":0.81671159029649598},{"$f":"absolute_disutility_AE_neutropenia","v":0.09},{"$f":"duration_AE_neutropenia","v":1.9},{"$f":"duration_AE_neutropenia/n_days_a_year","v":5.2054794520547945E-3},{"$f":"C6*D6","v":7.350404312668464E-2},{"$f":"G6*F6","v":3.8262378613890632E-4}]
[null,"Febrile neutropenia",{"$f":"p_AE_febrile_neutropenia_caba","v":7.5471698113207544E-2},{"$f":"absolute_disutility_AE_febrile_neutropenia","v":0.12},{"$f":"duration_AE_febrile_neutropenia","v":6.2},{"$f":"duration_AE_febrile_neutropenia/n_days_a_year","v":1.6986301369863014E-2},{"$f":"C7*D7","v":9.0566037735849043E-3},{"$f":"G7*F7","v":1.538382010855518E-4}]
[null,"Leukopenia",{"$f":"p_AE_leukopenia_caba","v":0.68194070080862534},{"$f":"absolute_disutility_AE_leukopenia","v":0.09},{"$f":"duration_AE_leukopenia","v":11.1},{"$f":"duration_AE_leukopenia/n_days_a_year","v":3.0410958904109588E-2},6.1374663072776281E-2,1.8664623564597718E-3]
[null,"Anaemia",{"$f":"p_AE_anaemia_caba","v":0.10512129380053908},{"$f":"absolute_disutility_AE_anaemia","v":0.125},{"$f":"duration_AE_anaemia","v":25.4},{"$f":"duration_AE_anaemia/n_days_a_year","v":6.9589041095890411E-2},1.3140161725067386E-2,9.1441125429236056E-4]
[null,"Diarrhoea",{"$f":"p_AE_diarrhoea_caba","v":6.1994609164420483E-2},{"$f":"absolute_disutility_AE_diarrhoea","v":4.7E-2},{"$f":"duration_AE_diarrhoea","v":8},{"$f":"duration_AE_diarrhoea/n_days_a_year","v":2.1917808219178082E-2},2.9137466307277626E-3,6.3862939851567401E-5]
[null,"Fatigue",{"$f":"p_AE_fatigue_caba","v":4.8517520215633422E-2},{"$f":"absolute_disutility_AE_fatigue","v":9.4E-2},{"$f":"duration_AE_fatigue","v":19.3},{"$f":"duration_AE_fatigue/n_days_a_year","v":5.2876712328767124E-2},4.5606469002695419E-3,2.4115201417863606E-4]
[null,"Asthenia",{"$f":"p_AE_asthenia_caba","v":4.5822102425876012E-2},{"$f":"absolute_disutility_AE_asthenia","v":9.4E-2},{"$f":"duration_AE_asthenia","v":13.3},{"$f":"duration_AE_asthenia/n_days_a_year","v":3.643835616438356E-2},4.3072776280323449E-3,1.5695011630912378E-4]
[null,null,null,null,null,null,null,{"$f":"SUM(H6:H12)","v":3.7793006683159176E-3}]
[]
[null,"Adverse event ","Incidence mitoxantrone (%)","Disutility","Duration (days)","Duration (years)","Total disutility by incidence","Total QALY lost"]
[null,null,"%(n/N)"]
["Mitoxantrone","Neutropenia",{"$f":"p_AE_neutropenia_mito","v":0.57951482479784366},{"$f":"absolute_disutility_AE_neutropenia","v":0.09},{"$f":"duration_AE_neutropenia","v":1.9},{"$f":"duration_AE_neutropenia/n_days_a_year","v":5.2054794520547945E-3},{"$f":"C17*D17","v":5.2156334231805927E-2},{"$f":"G17*F17","v":2.7149872613816783E-4}]
[null,"Febrile neutropenia",{"$f":"p_AE_febrile_neutropenia_mito","v":1.3477088948787063E-2},{"$f":"absolute_disutility_AE_febrile_neutropenia","v":0.12},{"$f":"duration_AE_febrile_neutropenia","v":6.2},{"$f":"duration_AE_febrile_neutropenia/n_days_a_year","v":1.6986301369863014E-2},{"$f":"C18*D18","v":1.6172506738544475E-3},{"$f":"G18*F18","v":2.7471107336705684E-5}]
[null,"Leukopenia",{"$f":"p_AE_leukopenia_mito","v":0.42318059299191374},{"$f":"absolute_disutility_AE_leukopenia","v":0.09},{"$f":"duration_AE_leukopenia","v":11.1},{"$f":"duration_AE_leukopenia/n_days_a_year","v":3.0410958904109588E-2},3.8086253369272238E-2,{"$f":"G19*F19","v":1.1582394860244433E-3}]
[null,"Anaemia",{"$f":"p_AE_anaemia_mito","v":4.8517520215633422E-2},{"$f":"absolute_disutility_AE_anaemia","v":0.125},{"$f":"duration_AE_anaemia","v":25.4},{"$f":"duration_AE_anaemia/n_days_a_year","v":6.9589041095890411E-2},6.0646900269541778E-3,4.22035963519551E-4]
[null,"Diarrhoea",{"$f":"p_AE_diarrhoea_mito","v":2.6954177897574125E-3},{"$f":"absolute_disutility_AE_diarrhoea","v":4.7E-2},{"$f":"duration_AE_diarrhoea","v":8},{"$f":"duration_AE_diarrhoea/n_days_a_year","v":2.1917808219178082E-2},1.266846361185984E-4,2.7766495587638003E-6]
[null,"Fatigue",{"$f":"p_AE_fatigue_mito","v":2.9649595687331536E-2},{"$f":"absolute_disutility_AE_fatigue","v":9.4E-2},{"$f":"duration_AE_fatigue","v":19.3},{"$f":"duration_AE_fatigue/n_days_a_year","v":5.2876712328767124E-2},2.7870619946091645E-3,1.473706753313887E-4]
[null,"Asthenia",{"$f":"p_AE_asthenia_mito","v":2.4258760107816711E-2},{"$f":"absolute_disutility_AE_asthenia","v":9.4E-2},{"$f":"duration_AE_asthenia","v":13.3},{"$f":"duration_AE_asthenia/n_days_a_year","v":3.643835616438356E-2},2.2803234501347709E-3,8.3091238046006715E-5]
[null,null,null,null,null,null,null,{"$f":"SUM(H17:H23)","v":2.1124838459550275E-3}]
[]
[]
[]
[null,"These numbers have to be added to the Parameters sheet (using alpha and beta) see instructions file"]

{"sheet":"Cabazitaxel+","index":5,"n_rows":272,"n_cols":69,"rows_kept":272,"cut":false,"hidden":false,"merged":[[2,46,2,52],[2,53,2,61],[2,62,2,64],[2,65,2,68],[269,46,270,68],[0,0,0,16],[0,17,0,27],[0,28,0,39],[0,40,0,41],[2,18,2,24],[2,25,2,33],[2,34,2,36],[2,37,2,40],[269,18,270,40],[2,10,2,11],[2,12,2,14],[2,43,2,44],[2,6,2,9]]}
["Model for Cabazitaxel+"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Not discounted - with half cycle correction - Display costs WITHOUT decimals",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Discounted - with half cycle correction - Display costs WITHOUT decimals"]
[null,null,null,null,null,null,"Number of patients in health states at start cycle",null,null,null,"Compared to previous cycle",null,"Number of patients in health state during cycle (half-cycle corrected)",null,null,null,null,null,"Costs SD",null,null,null,null,null,null,"Costs PD",null,null,null,null,null,null,null,null,"LYs",null,null,"QALYs  ",null,null,null,null,null,"Discount factors",null,null,"Costs SD",null,null,null,null,null,null,"Costs PD",null,null,null,null,null,null,null,null,"LYs",null,null,"QALYs  "]
["Cycle","Time in weeks","Time in months","OS","PFS",null,"Progression free (or stable disease)","Progression","Death","Check","Newly progressed","Newly died","Progression free (or stable disease)","Progression","Death",null,null,null,"Drug acquisition costs - SD","Premed costs SD","Concomitant costs SD","Chemo admin costs - SD","HC resource use SD","AE costs SD","Total costs SD","Drug acquisition costs post-progression chemo - PD","Premed costs PD","Chemo admin costs - PD","Concomitant costs PD","HC resource use PD","BSC costs","End of life costs ","Total costs PD","Total Costs","Years accrued in stable disease (SD)","Years accrued in progressed disease (PD)","Total Life-years","QALYs accrued in stable disease (SD)","QALYs accrued in progressed disease (PD)","QALYs lost due to adverse events","Total QALYs",null,"Year","Cost","Benefit",null,"Drug acquisition costs - SD","Premed costs SD","Concomitant costs SD","Chemo admin costs - SD","HC resource use SD","AE costs SD","Total costs SD","Drug acquisition costs post-progression chemo - PD","Premed costs PD","Chemo admin costs - PD","Concomitant costs PD","HC resource use PD","BSC costs","End of life costs ","Total costs PD","Total Costs","Years accrued in stable disease (SD)","Years accrued in progressed disease (PD)","Total Life-years","QALYs accrued in stable disease (SD)","QALYs accrued in progressed disease (PD)","QALYs lost due to adverse events","Total QALYs"]
[]
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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Average outcomes per patient over 15 years",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Average outcomes per patient over 15 years"]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Drug acquisition costs - SD","Premed costs - SD","Concomitant costs - SD","Chemo admin costs - SD","HC resource use SD","AE costs SD","Total costs SD","Drug acquisition costs post-progression chemo - PD","Premed costs PD","Chemo admin costs - PD","Concomitant costs PD","HC resource use PD","BSC costs","End of life costs ","Total costs PD","Total Costs","Years accrued - SD","Years accrued - PD","Total Life-years","QALYs accrued - SD","QALYs accrued - PD","QALYs lost due to adverse events","Total QALYs"]

{"sheet":"Mitoxantrone+","index":6,"n_rows":272,"n_cols":69,"rows_kept":272,"cut":false,"hidden":false,"merged":[[269,18,270,40],[269,46,270,68],[2,43,2,44],[2,46,2,52],[2,53,2,61],[2,62,2,64],[2,65,2,68],[0,28,0,39],[0,40,0,41],[2,6,2,9],[2,10,2,11],[2,12,2,14],[2,18,2,24],[2,25,2,33],[2,34,2,36],[2,37,2,40],[0,0,0,16],[0,17,0,27]]}
["Model for Mitoxantrone+"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Not discounted - with half cycle correction",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Discounted - with half cycle correction"]
[null,null,null,null,null,null,"Number of patients in health states at start cycle",null,null,null,"Compared to previous cycle",null,"Number of patients in health state during cycle (half-cycle corrected)",null,null,null,null,null,"Costs SD",null,null,null,null,null,null,"Costs PD",null,null,null,null,null,null,null,null,"LYs",null,null,"QALYs  ",null,null,null,null,null,"Discount factors",null,null,"Costs SD",null,null,null,null,null,null,"Costs PD",null,null,null,null,null,null,null,null,"LYs",null,null,"QALYs  "]
["Cycle","Time in weeks","Time in months","OS","PFS",null,"Progression free (or stable disease)","Progression","Death","Check","Newly progressed","Newly died","Progression free (or stable disease)","Progression","Death",null,null,null,"Drug acquisition costs - SD","Premed costs SD","Concomitant costs SD","Chemo admin costs - SD","HC resource use SD","AE costs SD","Total costs SD","Drug acquisition costs post-progression chemo - PD","Premed costs PD","Chemo admin costs - PD","Concomitant costs PD","HC resource use PD","BSC costs","End of life costs ","Total costs PD","Total Costs","Years accrued in stable disease (SD)","Years accrued in progressed disease (PD)","Total Life-years","QALYs accrued in stable disease (SD)","QALYs accrued in progressed disease (PD)","QALYs lost due to adverse events","Total QALYs",null,"Year","Cost","Benefit",null,"Drug acquisition costs - SD","Premed costs SD","Concomitant costs SD","Chemo admin costs - SD","HC resource use SD","AE costs SD","Total costs SD","Drug acquisition costs post-progression chemo - PD","Premed costs PD","Chemo admin costs - PD","Concomitant costs PD","HC resource use PD","BSC costs","End of life costs ","Total costs PD","Total Costs","Years accrued in stable disease (SD)","Years accrued in progressed disease (PD)","Total Life-years","QALYs accrued in stable disease (SD)","QALYs accrued in progressed disease (PD)","QALYs lost due to adverse events","Total QALYs"]
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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Average outcomes per patient over 15 years",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Average outcomes per patient over 15 years"]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Drug acquisition costs - SD","Premed costs - SD","Concomitant costs - SD","Chemo admin costs - SD","HC resource use SD","AE costs SD","Total costs SD","Drug acquisition costs post-progression chemo - PD","Premed costs PD","Chemo admin costs - PD","Concomitant costs PD","HC resource use PD","BSC costs","End of life costs ","Total costs PD","Total Costs","Years accrued - SD","Years accrued - PD","Total Life-years","QALYs accrued - SD","QALYs accrued - PD","QALYs lost due to adverse events","Total QALYs"]

{"sheet":"extrapolation","index":7,"n_rows":333,"n_cols":45,"rows_kept":333,"cut":false,"hidden":false,"merged":[[38,29,38,36],[38,37,38,44],[39,29,39,32],[39,33,39,36],[39,37,39,40],[39,41,39,44],[27,29,27,36],[27,37,27,44],[28,29,28,32],[28,33,28,36],[28,37,28,40],[28,41,28,44],[11,3,11,10],[11,11,11,18],[11,22,11,23],[11,25,11,26],[12,3,12,6],[12,7,12,10],[12,11,12,14],[12,15,12,18],[4,30,4,34],[4,36,4,40],[5,30,5,31],[5,33,5,34],[5,36,5,37],[5,39,5,40],[2,3,2,10],[2,11,2,18],[3,3,3,6],[3,7,3,10],[3,11,3,14],[3,15,3,18]]}
[null,null,"Do not make changes in the area with the red border!"]
[null,null,null,"Live values curve fitting"]
[null,null,null,"PFS",null,null,null,null,null,null,null,"OS",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Cholesky decompositions of variance - covariance matrices"]
[null,null,null,"Caba",null,null,null,"Mito",null,null,null,"Caba",null,null,null,"Mito",null,null,null,null,null,null,null,null,null,null,null,null,"Enter here output on the variance-covariance matrix from computer exercise, this will be used in the PSA assignment"]
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[]
[]
[null,null,null,"Extrapolated curves",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Observed KM data",null,null,null,null,null,null,null,null,"intercept","log(scale)",null,"intercept","log(scale)",null,"intercept","log(scale)",null,"intercept","log(scale)"]
[null,null,null,"PFS",null,null,null,null,null,null,null,"OS",null,null,null,null,null,null,null,null,null,null,"PFS",null,null,"OS",null,null,"Weibull","intercept",5.8986233259764403E-2,0,"intercept",6.1959260343002101E-2,0,"intercept",4.05087071958442E-2,0,"intercept",3.6738996258960301E-2,0]
[null,null,null,"Caba",null,null,null,"Mito",null,null,null,"Caba",null,null,null,"Mito",null,null,null,null,null,null,"Caba","Mito",null,"Caba ","Mito",null,null,"log(scale)",-1.13584878164005E-2,4.5296185073313601E-2,"log(scale)",-1.2817942542524E-2,4.0651112817211503E-2,"log(scale)",2.7524594863844701E-3,5.2550758737997402E-2,"log(scale)",-4.9250294049142202E-3,4.8097143908759903E-2]
["Cycle","Months","Weeks","exponential","Weibull","lognormal","loglogistic","exponential","Weibull","lognormal","loglogistic","exponential","Weibull","lognormal","loglogistic","exponential","Weibull","lognormal","loglogistic",null,null,"Time (months)","KM","KM","Time (months)","KM","KM"]
[0,0,0,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,null,null,0,1,1,0,1,1,null,null,null,"intercept","log(scale)",null,"intercept","log(scale)",null,"intercept","log(scale)",null,"intercept","log(scale)"]
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[{"$f":"+A16+1","v":2},{"$f":"12*C17/52","v":1.3846153846153846},{"$f":"+C16+3","v":6},{"$f":"EXP(-(EXP(-$D$7)*$B17))","v":0.72410820498077},{"$f":"EXP(-EXP(-($E$7/EXP($E$8)))*$B17^(1/EXP($E$8)))","v":0.70513573181764444},{"$f":"1 - _xlfn.NORM.S.DIST(((LN($B17) - $F$7)/EXP($F$8)), TRUE)","v":0.69756730437061321},{"$f":"1/(1+EXP(-($G$7/EXP($G$8)))*$B17^(1/EXP($G$8)))","v":0.70427701664317188},{"$f":"EXP(-(EXP(-$H$7)*$B17))","v":0.64130786299886045},{"$f":"EXP(-EXP(-($I$7/EXP($I$8)))*$B17^(1/EXP($I$8)))","v":0.60203300226568479},{"$f":"1 - _xlfn.NORM.S.DIST(((LN($B17) - $J$7)/EXP($J$8)), TRUE)","v":0.59586884971951193},{"$f":"1/(1+EXP(-($K$7/EXP($K$8)))*$B17^(1/EXP($K$8)))","v":0.57777566141484082},{"$f":"EXP(-(EXP(-$L$7)*$B17))","v":0.93684229458309731},{"$f":"EXP(-EXP(-($M$7/EXP($M$8)))*$B17^(1/EXP($M$8)))","v":0.98236072478357817},{"$f":"1 - _xlfn.NORM.S.DIST(((LN($B17) - $N$7)/EXP($N$8)), TRUE)","v":0.99572874637214026},{"$f":"1/(1+EXP(-($O$7/EXP($O$8)))*$B17^(1/EXP($O$8)))","v":0.99127262564903595},{"$f":"EXP(-(EXP(-$P$7)*$B17))","v":0.91676720267903378},{"$f":"EXP(-EXP(-($Q$7/EXP($Q$8)))*$B17^(1/EXP($Q$8)))","v":0.9794984285779238},{"$f":"1 - _xlfn.NORM.S.DIST(((LN($B17) - $R$7)/EXP($R$8)), TRUE)","v":0.99584914784313916},{"$f":"1/(1+EXP(-($S$7/EXP($S$8)))*$B17^(1/EXP($S$8)))","v":0.99157540489059759},null,null,1.5,0.65,0.42,3,0.95499999999999996,0.96,null,null,"log(scale)",-1.9259391565363099E-3,4.4589058080668702E-2,"log(scale)",-3.0971769011950102E-3,4.2669435266441E-2,"log(scale)",8.5480087044055904E-3,4.6096762087328103E-2,"log(scale)",4.1970333435666501E-3,4.3647423052517197E-2]
[3,2.0769230769230771,9,0.61617660195250312,0.59900555223237217,0.56724739373757704,0.57287070447161004,0.51357023712526839,0.48246861161693261,0.44517943414250993,0.41760025931006017,0.90677540852569261,0.96784301182824184,0.98543533057728594,0.98077603564159865,0.8777859032574048,0.96144122022081446,0.9837814685385019,0.97967134722626381,null,null,{"$f":"+V17+0.75","v":2.25},0.55000000000000004,0.36,4.5,0.91,0.89500000000000002]
[4,2.7692307692307692,12,0.52433269252047288,0.51038982091468077,0.46908422159729612,0.4715780194773509,0.41127577514416519,0.3897224254685715,0.34169839741512487,0.31191615984089893,0.87767348491972297,0.95093236189779684,0.96882467044161036,0.9665712029173259,0.84046210390794052,0.93991786154614609,0.96277412570010679,0.96237100020513722,null,null,{"$f":"+V18+0.75","v":3},0.45,0.3,6,0.86,0.82499999999999996]
[5,3.4615384615384617,15,0.4461785331909775,0.43584642141495039,0.39392034010397237,0.39417358833490196,0.32935663127062387,0.31660428641050187,0.26853599120261396,0.24106482018015912,0.84950555439473541,0.93211163380560924,0.9470805095221797,0.94901432406929065,0.80472532708037992,0.91560507899416421,0.93426714610518546,0.93992447914597788,null,null,3.75,0.39,0.27,{"$f":"+Y19+1.5","v":7.5},0.81,0.74,null,null,null,"intercept","log(scale)",null,"intercept","log(scale)",null,"intercept","log(scale)",null,"intercept","log(scale)"]
[6,4.1538461538461542,18,0.37967360479373352,0.37283842375044551,0.33519305628567808,0.33448125775625598,0.26375438846090438,0.25834661321370811,0.21524576603061107,0.19193937253695062,0.82224164150693668,0.91173715478443562,0.92156621311117215,0.92850834920553116,0.7705080919574181,0.88903232814711497,0.90030011536185817,0.91282855152084152,null,null,4.5,0.3,0.2,{"$f":"+Y20+1.5","v":9},0.76,0.68,null,"Loglogistic","intercept",6.4091215563293794E-2,0,"intercept",5.67696803186672E-2,0,"intercept",4.5823304861142201E-2,0,"intercept",4.1296344803834997E-2,0]
[7,4.8461538461538458,21,0.32308153676987167,0.31939631277180869,0.28844297837704669,0.28776222320417344,0.21121899736466751,0.21157179389375833,0.17540553394565273,0.15667718561218877,0.79585273284025015,0.89009307149063766,0.89349343370323508,0.90548602253718014,0.73774578703245042,0.86064187220679178,0.8627938882788152,0.88175817551452795,null,null,5.25,0.28000000000000003,0.18,10.5,0.7,0.58499999999999996,null,null,"log(scale)",-9.82529676605434E-4,4.8765523785077203E-2,"log(scale)",1.4182735783144101E-3,4.8035516760660098E-2,"log(scale)",4.3699405641120601E-3,5.24099132538874E-2,"log(scale)",1.01661884507266E-3,4.93920534473846E-2]
[8,5.5384615384615383,24,0.27492477244576874,0.27394735132924486,0.25061338690791835,0.25060845162905582,0.16914776322043393,0.17379356935020865,0.14495182780843407,0.13056170676235251,0.77031074613113115,0.86741651368081851,0.8638426732868898,0.88039220338259971,0.70637654810536188,0.83081635263404963,0.82332420811205576,0.84749795684796658,null,null,6,0.25,0.16,12,0.65,0.54]
[9,6.2307692307692308,27,0.2339459916528604,0.2352136420361616,0.21956469539663526,0.22060206177809641,0.13545640382469684,0.1431357064387217,0.12122814198898602,0.11068739798022441,0.7455885003842887,0.8439110875130359,0.8333722563744006,0.85366747625867312,0.67634114146598179,0.79989332717759321,0.78309830140774306,0.8108767949479051,null,null,6.75,0.23,0.14000000000000001,13.5,0.56999999999999995,0.46500000000000002]
[10,6.9230769230769234,30,0.1990752834804522,0.20214468040880657,0.19376529121171104,0.1960194270560755,0.10847579056193371,0.11815737008326593,0.10244407828612256,9.520502454050736E-2,0.72165968694750671,0.81975486370885675,0.80265309107995564,0.82573422420302656,0.64758285204462451,0.76817371009559532,0.74300189097661673,0.77271095284928348,null,null,7.5,0.21,0.12,15,0.5,0.4]
[11,7.615384615384615,33,0.16940221207819894,0.17386967314197163,0.17209536787623447,0.1756170801274658,8.686925686632703E-2,9.7737641172660872E-2,8.7359855142655318E-2,8.2899122110381168E-2,0.69849884151478758,0.79510546639543234,0.77210646792205484,0.79698576800588683,0.6200473763185127,0.73592706439088584,0.7036624339777996,0.73375951783641857,null,null,8.25,0.19,0.11,16.5,0.45,0.32,null,"Enter output from R in table below",null,null,null,null,null," Display values with max 4 decimals"]
[12,8.3076923076923084,36,0.14415204617706817,0.14966228187119515,0.15372037916356784,0.15848482720382431,6.9566377432385668E-2,8.0995685588860625E-2,7.5096300001188832E-2,7.2946655821117923E-2,0.67608131702802188,0.77010350932359117,0.74203744491220314,0.76777873084401038,0.59368271977186104,0.70339515915407558,0.66550852084340162,0.69469394583894672,null,null,9,0.18,0.09,18,0.39500000000000002,0.28499999999999998,null,null,"Deterministic "]
[13,9,39,0.12266553170771634,0.12891371914400432,0.13800762073541395,0.14394628558595729,5.5709937481243248E-2,6.7233752982492248E-2,6.5016785818471701E-2,6.4775157839897984E-2,0.6543832574483488,0.74487503225372553,0.71266211524352263,0.73842845909697585,0.56843909871599707,0.67079452842301113,0.62881942227471455,0.65608120432897876,null,null,9.75,0.14000000000000001,7.0000000000000007E-2,19.5,0.37,0.25,null,null,"PFS",null,null,null,null,null,null,null,"OS"]
[14,9.6923076923076916,42,0.10438167940158195,0.11111174301879914,0.12447001275499647,0.13149134528017065,4.4613464847735422E-2,5.5895469770002752E-2,5.665173181254568E-2,5.7976775795273411E-2,0.63338157236929449,0.71953330364913215,0.684129085971936,0.70920711391251368,0.54426884628412975,0.6383184393991298,0.59376422225978431,0.61837848379933225,null,null,10.5,0.1,0.05,21,0.32500000000000001,0.21,null,null,"Caba",null,null,null,"Mito",null,null,null,"Caba",null,null,null,"Mito"]
[15,10.384615384615385,45,8.8823117977886196E-2,9.5823974963230515E-2,0.11272740980206586,0.12072986143032094,3.5727220953896223E-2,4.6534738157715486E-2,4.9649054097002043E-2,5.2254651779596317E-2,0.61305391244467289,0.69418020641760292,0.65653609095517274,0.68034393370970114,0.52112632242325574,0.60613850587415585,0.56043184341705499,0.58193667629418822,null,null,11.25,0.09,4.4999999999999998E-2,22.5,0.31,0.17499999999999999,null,null,"exponential","Weibull","lognormal","loglogistic","exponential","Weibull","lognormal","loglogistic","exponential","Weibull","lognormal","loglogistic","exponential","Weibull","lognormal","loglogistic"]
[16,11.076923076923077,48,7.5583630504357707E-2,8.2684477392096653E-2,0.10247945121857749,0.11135949891947923,2.8610965802475984E-2,3.8792191497266634E-2,4.3740880631374268E-2,4.7388546786763006E-2,0.59337864560510001,0.66890734065872837,0.62994271990271034,0.652027135888818,0.4989678277132466,0.57440608720707953,0.52885370039982238,0.54700970978521568,null,null,12,0.08,0.04,24,0.28000000000000003,0.15,null,"AIC",1885.1070999999999,1885.5943,1886.6016,1895.3381999999999,1754.2742000000001,1748.7375,1691.7935,1695.7627,1987.5033000000001,1939.5374999999999,1952.9809,1938.9274,2019.9897000000001,1948.8255999999999,1966.3670999999999,1948.9386]
[17,11.76923076923077,51,6.4317548519762319E-2,7.1382843311683222E-2,9.3486167963392375E-2,0.1031430947247868,2.2912147720831295E-2,3.2377150419696965E-2,3.8720719341892251E-2,4.3212244762682255E-2,0.5743348340378126,0.64379692915175302,0.60438012484744053,0.6244069531947265,0.47775152085038042,0.54325355759687666,0.49902061142218945,0.51376715944851714,null,null,12.75,0.06,3.5000000000000003E-2,25.5,0.25,0.13500000000000001,null,"intercept",1.4560999999999999,1.4382999999999999,0.92820000000000003,0.93820000000000003,1.1368,1.0851,0.58399999999999996,0.5222,3.0550999999999999,3.0125000000000002,2.7050000000000001,2.7229999999999999,2.7684000000000002,2.778,2.4634999999999998,2.4904999999999999]
[18,12.461538461538462,54,5.4730727010440225E-2,6.165525557151616E-2,8.5553903642010098E-2,9.5892497592824366E-2,1.8348437337119342E-2,2.7053653931858716E-2,3.4427499066048584E-2,3.9598356732471876E-2,0.55590221190529243,0.6189225820387213,0.57985840438373448,0.59759936373628664,0.45743733963950717,0.51279549682087411,0.47089533012756613,0.48230810691093334,null,null,13.5,0.04,0.03,27,0.25,0.12,null,"log(scale)",null,5.6599999999999998E-2,0.1527,-0.34789999999999999,null,0.1132,6.3500000000000001E-2,-0.4662,null,-0.40500000000000003,-0.1,-0.68,null,-0.45789999999999997,-0.2107,-0.78949999999999998]
[19,13.153846153846153,57,4.6572864607408691E-2,5.3277111692525733E-2,7.8524941361866274E-2,8.9456873881963495E-2,1.4693740491560529E-2,2.2629552962669379E-2,3.0734223251710602E-2,3.6447886846905676E-2,0.53806116377898683,0.5943499587495531,0.55637221491644717,0.5716901545309836,0.43798692534565736,0.48312983275719285,0.44442177646088232,0.45267481353915034,null,null,14.25,0.03,2.5000000000000001E-2,28.5,0.23,0.12,null,"Do not make changes in the area within the red border!"]
[20,13.846153846153847,60,3.963096849282241E-2,4.6056906968788301E-2,7.226975717452222E-2,8.3714134346333582E-2,1.1766997138036507E-2,1.8947933220362256E-2,2.7539777876602667E-2,3.3682931155117869E-2,0.52079270376517339,0.57013735329750381,0.53390503181180804,0.54673904249720895,0.41936355026225003,0.45433895280917902,0.41953179690015041,0.42486530757736057,null,null,15,0.02,0.02,30,0.19,0.12,null,null,"Random Values N(0, 1)"]
[21,14.538461538461538,63,3.3723793391683146E-2,3.9831138053061675E-2,6.6681163163170298E-2,7.8564570807103093E-2,9.4232113141025087E-3,1.5880327793847029E-2,2.4762933171566082E-2,3.1241479499779616E-2,0.50407845530075768,0.54633622116268588,0.51243238304117944,0.52278365486320189,0.40153204835912903,0.42649079290884689,0.39615008335678992,0.39884440874821736,null,null,15.75,1.4999999999999999E-2,1.7500000000000002E-2,null,null,null,null,null,{"$f":"_xlfn.NORM.INV(RAND(),0,1)","v":0.29337695592804269},{"$f":"_xlfn.NORM.INV(RAND(),0,1)","v":-0.8672288272521893},-0.90958642005410406,-0.16062048071454604,-2.0112119558625094,-1.7301647544498884,-0.13146965786825171,-0.99616079287246795,-0.22197759024390265,-0.59931481612014603,-0.13798739508152408,1.2522580594666133,3.6069245164555334E-2,-0.23979938717529542,-0.25430337875305642,-0.52633365840295543]
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{"sheet":"curve PFS mito ","index":9,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[]}

{"sheet":"curve OS caba","index":10,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[]}

{"sheet":"curve OS mito","index":11,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[]}

{"sheet":"estimation life years","index":12,"n_rows":7,"n_cols":12,"rows_kept":7,"cut":false,"hidden":false,"merged":[]}
[]
[null,"Estimation Life years",null,null,null,null,null,"Estimation PF life years"]
[null,null,"Mito","Caba","Incremental (years)","Incremental (months)",null,null,"Mito","Caba","Incremental (years)","Incremental (months)"]
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[null,"Exponential",1.3568135537192045,1.7975499899825143,{"$f":"+D5-C5","v":0.44073643626330972},{"$f":"+E5*12","v":5.2888372351597166},null,"Exponential",0.28964473313634265,0.38705506257823663,{"$f":"+J5-I5","v":9.7410329441893984E-2},{"$f":"+K5*12","v":1.1689239533027278}]
[null,"Lognormal",1.3870267908001626,1.8959466141180916,{"$f":"+D6-C6","v":0.50891982331792907},{"$f":"+E6*12","v":6.1070378798151488},null,"Lognormal",0.2924330658827996,0.44397263345836974,{"$f":"+J6-I6","v":0.15153956757557013},{"$f":"+K6*12","v":1.8184748109068416}]
[null,"Loglogistic",1.4526138156777868,1.9512316700431049,{"$f":"+D7-C7","v":0.49861785436531814},{"$f":"+E7*12","v":5.9834142523838176},null,"Loglogistic",0.31658639676944966,0.54108092255166707,{"$f":"+J7-I7","v":0.2244945257822174},{"$f":"+K7*12","v":2.6939343093866088}]

{"sheet":"Simulation","index":13,"n_rows":1017,"n_cols":32,"rows_kept":1017,"cut":false,"hidden":false,"merged":[[9,11,9,18],[9,21,9,23],[9,29,9,31],[9,42,9,43],[0,2,0,10],[3,21,3,23],[3,29,3,31],[4,2,4,6],[4,42,4,43]]}
[null,null,"Cost effectiveness of cabazitaxel for the second line treatment of hormone refractory metastatic prostate cancer"]
[]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Aceptability curves"]
[null,null,"Treatment outcome (discounted)",null,null,null,null,null,null,null,null,"Incremental outcomes (discounted)",null,null,null,null,null,null,null,null,"Net monetary benefits",null,null,null,null,"Cost effective?"]
[]
[null,null,null,"CostCaba+","CostMito+","LYCaba+","LYMito+","QALYCaba+","QALYMito+",null,null,null,"Cost","LY","QALY",null,null,null,null,null,"Threshold","Caba+","Mito+","Increment",null,"Caba+","Mito+",null,null,null,"Treatment","BSC"]
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